Bring the life stages into the domain of basic and clinical pharmacology
Source : https://www.frontiersin.org/articles/10.3389/fphar.2022.923016/full
Completely distinct physiological conditions and immune responses exist among different human life stages. Age is not always consistent with the life stage. We proposed to incorporate the concept of the...
Conclusion: No matter influenced by which factors, life stages such as puberty and menopause are the indication of significant changes in human development. Because the ages of puberty among individuals or ethnic groups are different, instruction of doses is better based on puberty rather than ages.
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Novel insights into reproductive ageing and menopause from genomics - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36478237/
The post-reproductive phase or menopause in females is triggered by a physiological timer that depends on a threshold of follicle number in the ovary. Curiously, reproductive senescence appears to be...
Conclusion: Recent large scale genomic studies have started to elucidate how genetic variation affects variation in the ANM and importantly has informed functional experiments targeting specific molecular players for pharmacological or life-style treatments. Following the example of other complex traits, larger cohorts are anticipated to expand...
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EP089/#784 Low use of hormone therapy in women with early menopause arising from treatment for cervical cancer
Source : https://ijgc.bmj.com/content/32/Suppl_3/A84.2
Objectives Many cervical cancer patients are premenopausal at diagnosis, and the treatment induces early menopause. The aim of this study was to evaluate the frequency of hormone replacement therapy (HRT)...
Conclusion: A small percentage of cervical cancer survivors have adequate information about menopause and HRT, and a smaller proportion receive hormone replacement therapy. These data show the need for attention to these young women who have menopause arising from treatment, and reinforce the importance for survivorship guidelines for cervical...
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Association of ß-glucuronidase activity with menopausal status, ethnicity, adiposity, and inflammation in women
le is known about ß-glucuronidase regulation across women's reproductive lifespan. Correlates of serum ß-glucuronidase activity in healthy premenopausal versus postmenopausal women were therefore examined. Methods ß-Glucuronidase activity and C-reactive protein...
Conclusion: ß-Glucuronidase enzyme activity, upon which polyphenol health-related benefits may depend, is not associated with menopausal status. Future studies are required to determine clinical significance and mechanisms driving ß-glucuronidase associations with ethnicity, inflammation, and adiposity in women.
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Heart Failure in Menopause: Treatment and New Approaches
Source : https://www.mdpi.com/1422-0067/23/23/15140/htm
Aging is an important risk factor for the development of heart failure (HF) and half of patients with HF have preserved ejection fraction (HFpEF) which is more common in elderly...
Conclusion: Despite all the advances in considering the best options to treat menopause-induced HFpEF, which involves the reduction of cardioprotection due to estrogen depletion, the focus should be the modulation of the RAS and sympathetic system. The combination of the alternatives described and lifestyle changes including physical activity...
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