Conclusion: These findings suggest that systemically administered HT before and during menopause is associated with higher risk of depression, especially in the years immediately after initiation, whereas locally administered HT is associated with lower risk of depression for women 54 years or older.
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Conclusion: In this randomized clinical trial, 8-wk combined treatment with PFMT EA led to a greater improvement in SUI symptoms and better outcomes than with PFMT sham EA.
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Can precision medicine get us through menopause?
Source : https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(22)00544-8/fulltext
Women spend up to three decades in the post-menopausal phase of life, which is often accompanied by a wide variety of life-disrupting symptoms, including vasomotor symptoms, sleep disturbances, cognitive decline,...
Discussion: Using the comprehensive broad database generated, statistical mediation analyses were performed to lend insight into mechanisms driving the observed changes. These analyses revealed some novel and potentially important associations between diet, gut microbial changes, and health indicators.
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Lactobacilli and Cytokine Modifications during Menopause and Their Relation to Vulvar and Vulvovaginal Disorders
Source : https://e-jmm.org/DOIx.php?id=10.6118/jmm.22001
Lactobacilli and Cytokine Modifications during Menopause and Their Relation to Vulvar and Vulvovaginal Disorders Kushal Gandhi,Nathan Joshua Manales,John Garza,Samuel David,Asley Sanchez, 1 1 1 3 1 and Gary Ventolini 1...
Conclusion: The levels of vaginal cytokine and Lactobacillus profile were significantly different between the pre-menopausal and post-menopausal groups.
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"Let's see what happens:"-Women's experiences of open-label placebo treatment for menopausal hot flushes in a randomized controlled trial
Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0276499
Open-label (honestly prescribed) placebos are an ethical way to evoke placebo effects in patients. As part of a mixed-methods study, we conducted in-depth interviews with eight menopausal women who underwent...
Discussion: The patient interviews with menopausal women who benefitted from OLP treatment as part of an RCT indicate that placebos administered without deception and embedded in a clinical context can elicit salubrious benefits. Participants noted that they had an initially positive, curious, and “couldn’t hurt” attitude towards...
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