Alterations in the Mammary Gland and Tumor Microenvironment of Formerly Obese Mice
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10693119/
Obesity is a risk factor for breast cancer, and women with obesity that develop breast cancer have a worsened prognosis. Within the mammary gland, obesity causes chronic, macrophage-driven inflammation and...
Although weight loss did not completely reduce the rate of tumor growth, the microenvironment of the resulting tumors was less fibrotic and immunosuppressive than tumors from obese mice.
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Social Jetlag and Obesity: a Systematic Review and Meta-Analysis
Source : https://pubmed.ncbi.nlm.nih.gov/38072635/
Social jetlag, the weekly variation in sleep timing, is proposed to contribute to increased obesity risk, potentially because of the misalignment of behavioral cycles relative to the endogenous circadian timing...
Social jetlag, the weekly variation in sleep timing, was positively and consistently associated with multiple obesity-related anthropometric measures.
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Team-Based Learning Intervention to Improve Obesity Education in Medical School
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10689578/
Obesity is a multifactorial chronic disease and a major contributor to numerous health conditions. Despite the high prevalence, costs, and health effects of obesity, physicians are largely unprepared to treat...
Medical student attitudes toward obesity and self-perceived knowledge of obesity significantly improved after a 2-part team-based learning (TBL) seminar on obesity pathogenesis and treatment. As TBLs are being increasingly utilized in medical curricula across the country, this study provides a model to improve obesity education at the...
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Effects of Semaglutide on Symptoms, Function, and Quality of Life in Patients With Heart Failure With Preserved Ejection Fraction and Obesity: a Prespecified Analysis of the STEP-HFpEF Trial
Source : https://pubmed.ncbi.nlm.nih.gov/37952180/
Patients with heart failure (HF) with preserved ejection fraction (HFpEF) and obesity experience high burden of symptoms and functional impairment, and a poor quality of life.
In patients with HFpEF and obesity, semaglutide produced large improvements in HF-related symptoms, physical limitations, exercise function, inflammation, body weight and NTproBNP regardless of baseline health status.
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Effects of Combined Aerobic Exercise and Diet on Cardiometabolic Health in Patients With Obesity and Type 2 Diabetes: a Systematic Review and Meta-Analysis
Source : https://bmcsportsscimedrehabil.biomedcentral.com/articles/10.1186/s13102-023-00766-5
Lifestyle modifications involving diet and exercise are recommended for patients diagnosed with obesity and type 2 diabetes mellitus (T2DM). The purpose of this review was to systematically evaluate the effects...
The study results indicated that AEDT exerts beneficial changes in body composition, lipid and glucose metabolism, blood pressure, adipose tissue dysfunction, and inflammation in patients with T2DM and concurrent obesity.
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