Obesity and body mass index: Past and future considerations in osteoarthritis research
Source : https://pubmed.ncbi.nlm.nih.gov/38354848/
Obesity is an important topic for the osteoarthritis (OA) scientific community. However, the predominant use of body mass index (BMI) to define obesity in OA research is associated with uncertainties...
Future OA research should adopt alternative measures beyond BMI to accurately identify obesity, consider evolving obesity science, and minimize weight stigma to enhance health outcomes for those with or at risk for OA.
Therapeutic advances in obesity management: an overview of the therapeutic interventions
Source : https://pubmed.ncbi.nlm.nih.gov/38715796/
Obesity has become a global epidemic in the modern world, significantly impacting the global healthcare economy. Lifestyle interventions remain the primary approach to managing obesity, with medical therapy considered a...
The future of obesity management may hinge on personalized medicine, targeting specific components for novel therapeutic agents, while leveraging the efficacy of GLP-1 RAs and bariatric surgery for comprehensive treatment.
Obesity, heart failure with preserved ejection fraction, and the role of glucagon-like peptide-1 receptor agonists
Source : https://pubmed.ncbi.nlm.nih.gov/38093506/
Heart failure with preserved ejection fraction (HFpEF) has a high prevalence, affecting more than 50% of patients with heart failure. HFpEF is associated with multiple comorbidities, and obesity is one...
GLP-1 receptor agonists show promise for treating obese patients with HFpEF by promoting weight loss and improving metabolic function, but efficacy and safety must be confirmed through clinical trials.
Obesity-induced blood-brain barrier dysfunction: phenotypes and mechanisms
Source : https://pubmed.ncbi.nlm.nih.gov/38678254/
Obesity, a burgeoning global health issue, is increasingly recognized for its detrimental effects on the central nervous system, particularly concerning the integrity of the blood-brain barrier (BBB). This manuscript delves...
Obesity-induced BBB dysfunction is crucial for addressing neurodegenerative disease risks and developing targeted therapies, emphasizing the need for continued research in this critical area of neurological health.
Obesity and male fertility disorders
Source : https://pubmed.ncbi.nlm.nih.gov/38593513/
Often associated with obesity, male infertility represents a widespread condition that challenges the wellbeing of the couple. In this article, we provide a comprehensive and critical analysis of studies exploring...
Increased body weight negatively impacts male reproductive health through various molecular mechanisms, necessitating further research to enhance diagnostic markers and therapeutic strategies for better management of male infertility.