Mean changes in bodyweight from baseline to week 46 were –6.2%, –12.5%, –13.2%, –14.9%, and –2.8%.
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In this cross-sectional study of 5229 individuals, prevalence of obesity was highest among people who identified as Asian, Pacific Islander, and White (52.0%).
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These findings suggest that sarcopenic obesity may be associated with worse survival, and conducting screening for muscle function may help prevent premature death among older people.
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Efficacy and Safety of Once Weekly Semaglutide 2·4 mg for Weight Management in a Predominantly East Asian Population With Overweight or Obesity (STEP 7): a Double-Blind, Multicentre, Randomised Controlled Trial
Source : https://pubmed.ncbi.nlm.nih.gov/38330988/
For the Mandarin, Portuguese and South Korean translations of the abstract see Supplementary Materials section.
At week 44, the proportion of participants who lost 5% or more of their bodyweight was higher in the semaglutide 2.4 mg group than in the placebo group.
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Exploring the Association Between Suicidal Thoughts, Self-Injury, and GLP-1 Receptor Agonists in Weight Loss Treatments: Insights From Pharmacovigilance Measures and Unmasking Analysis
Source : https://pubmed.ncbi.nlm.nih.gov/38508100/
With the current pharmacovigilance approach, no causality link between suicidal ideation and use of any GLP-1 RA can be inferred. There is a need for further research and vigilance in...
The authors postulated that rapid weight loss achieved with GLP-1 receptor agonists could potentially trigger significant emotional, biologic, and psychological responses, possibly impacting suicidal and self-injurious ideations.
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