Efficacy and safety of tirzepatide for treatment of overweight or obesity. A systematic review and meta-analysis - International Journal of Obesity
Source : https://www.nature.com/articles/s41366-023-01321-5
Recent studies suggest that tirzepatide, a dual glucose-dependent insulinotropic-peptide (GIP) and glucagon-like peptide-1 receptor agonist (GLP-1 RA), has significant weight loss effects. This systematic review and meta-analysis aims to assess...
Conclusion: Tirzepatide has significant potential as a weight loss drug in patients with overweight and obesity, with little increase in AEs compared to other weight loss drugs. With its ability to concurrently target multiple aspects of metabolic syndrome, it should be considered as the next helm of weight loss therapies.
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Relevance: Can behavioral interventions designed to treat childhood obesity be delivered in pediatric primary care settings?
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Role of Glucagon-Like Peptide-1 Receptor Agonists in Achieving Weight Loss and Improving Cardiovascular Outcomes in People With Overweight and Obesity - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37278394/
Obesity remains a major public health problem, affecting almost half of adults in the United States. Increased risk of cardiovascular disease (CVD) and CVD mortality are major obesity-related complications, and...
Conclusions: The evidence discussed in this article demonstrates that GLP‐1 RAs should be strongly considered as an option for use in clinical practice for the treatment of obesity and reduction of CVD risk in people with T2D.
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Design and Baseline Characteristics of STEP-HFpEF Program Evaluating Semaglutide in Patients With Obesity HFpEF Phenotype
Source : https://www.sciencedirect.com/science/article/pii/S2213177923002457?via=ihub
Available online 21 May 2023 Author links open overlay panel a , , , d e , , f g , , , , , i , , , k...
Conclusions: In total, STEP-HFpEF program randomized 1,146 participants with the obesity phenotype of HFpEF and will determine whether semaglutide improves symptoms, physical limitations, and exercise function in addition to weight loss in this vulnerable group.
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Adaptation of a Mobile Interactive Obesity Treatment Approach for Early Severe Mental Illness: Protocol for a Mixed Methods Implementation and Pilot Randomized Controlled Trial
Source : https://www.researchprotocols.org/2023/1/e42114
Background: Obesity is common in individuals with severe mental illness (SMI), contributing to a significantly shortened lifespan when compared to the general population. Available weight loss treatments have attenuated efficacy...
Conclusions: In this type 1 hybrid study design, we apply an evidence-based treatment adaptation framework to plan, adapt, and feasibility test a mobile health intervention in real-world treatment settings. Resting at the intersection of community mental health treatment and physical health promotion, this study aims to advance the use of...
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