Obesity, white adipose tissue and cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39496581/
White adipose tissue (WAT) is crucial for whole-body energy homeostasis and plays an important role in metabolic and hormonal regulation. While healthy WAT undergoes controlled expansion and contraction to meet...
Obesity-induced white adipose tissue dysfunction alters metabolism and inflammation, promoting cancer through systemic and local tumor interactions, extracellular remodeling, and reciprocal signaling, highlighting therapeutic intervention opportunities.
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The promise of tirzepatide: A narrative review of metabolic benefits - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40221292/
Obesity and type 2 diabetes mellites (T2DM) are intertwined epidemics that continue to pose significant challenges to global public health. We aim to review the available evidence on the metabolic...
Tirzepatide offers significant metabolic benefits, inducing substantial weight and fat loss, appetite suppression, improved glycemic and lipid profiles, with manageable side effects, supporting its promise for obesity and T2DM management.
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Complementary Food and Obesity - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39832488/
Obesity, characterized by excess body fat and numerous complications, arises from a combination of genetic susceptibility and an obesogenic environment, including lifestyle behaviors related to energy balance. Eating habits start...
Early infant feeding shapes obesity risk; solid food timing, feeding methods, parental practices, and socioeconomic factors influence outcomes. Early prevention via responsive feeding education improves long-term health.
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Key Gaps in the Prevention and Treatment of Obesity in Children and Adolescents: A Critical Appraisal of Clinical Guidelines - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40150629/
Standardizing BMI cut-off points and defining age groups across CPGs would improve consistency and comparability in the diagnosis, prevention, and treatment of childhood obesity. Tailoring recommendations for diet, physical activity,...
Current childhood obesity guidelines lack age-specific recommendations and standardization, especially in BMI criteria, dietary details, and parental roles. Enhancing precision and updating treatment options are crucial for effective interventions.
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An orally active carbon monoxide-releasing molecule enhances beneficial gut microbial species to combat obesity in mice - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38608580/
Carbon monoxide (CO), a gaseous signaling molecule, has shown promise in preventing body weight gain and metabolic dysfunction induced by high fat diet (HFD), but the mechanisms underlying these effects...
Carbon monoxide delivered via CORM-401 reshapes gut microbiota disrupted by a high-fat diet, notably restoring Akkermansia muciniphila, normalizing metabolites, improving gut health, and mitigating inflammation and metabolic dysfunction in mice.
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