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    No two people experience obesity in exactly the same way, especially in kids and teenagers. For some, it’s about appetite feeling stronger or harder to control. For others, it’s how Show More
  • 2d
    What strikes me about applying phenotype-guided care to pediatric and adolescent obesity specifically is that we're trying to characterize a moving target. An adult's metabolic and behavioral phenotype tends to Show More

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4d
Longitudinal analysis of short-chain fatty acid profiles in stool of sleeve gastrectomy patients. - PubMed

Longitudinal analysis of short-chain fatty acid profiles in stool of sleeve gastrectomy patients. - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/42276984

Discover how sleeve gastrectomy affects gut microbiota, altering SCFA profiles over 12 months and influencing metabolic and psychological outcomes.


Sleeve gastrectomy alters faecal SCFA profiles over 12 months, with decreased major SCFAs and increased branched SCFAs, suggesting gut microbiota shifts.

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2w
Physical activity and anthropometric factors as predictors for postural stability in children - PubMed

Physical activity and anthropometric factors as predictors for postural stability in children - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/42203825/

To determine whether anthropometric factors and different domains of physical activity are associated with postural stability outcomes in children. Ninety-five children aged 7-18 years were enrolled in a cross-sectional observational...

Cross-sectional study found that postural stability in children is influenced by age, physical activity, physical education performance, and body weight, with overweight/obesity associated with poorer balance measures and sports participation potentially mitigating some deficits.

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3w
Glucagon-Like Peptide-1 Receptor Agonist and Hyponatremia: A Potential Association - PubMed

Glucagon-Like Peptide-1 Receptor Agonist and Hyponatremia: A Potential Association - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/42149072/

Clinicians should consider monitoring serum sodium in patients receiving GLP-1 receptor agonists, particularly when used alongside medications affecting sodium balance, such as thiazide-like diuretic agents.

Case suggests a potential association between tirzepatide and recurrent hyponatremia, particularly with concomitant chlorthalidone use, highlighting the importance of serum sodium monitoring during GLP-1 receptor agonist therapy.

 

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3w
Leptin and leptin resistance in obesity: current evidence, mechanisms and future directions - PubMed

Leptin and leptin resistance in obesity: current evidence, mechanisms and future directions - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/40932169/

Leptin, a key adipokine regulating energy homeostasis, has been extensively studied for its potential in the management of obesity. However, its therapeutic efficacy is often limited due to leptin resistance....

This review examines leptin biology and mechanisms of leptin resistance in obesity, highlighting impaired signaling pathways, inflammation, and hyperleptinemia while discussing emerging strategies including leptin sensitization, combination therapies, and MC4R agonists.

 

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