Once-Weekly Subcutaneous Semaglutide 2.4 mg Injection is Cost-Effective for Weight Management in the United Kingdom - Advances in Therapy
Source : https://link.springer.com/article/10.1007/s12325-022-02423-8
Objectives The objective of the current preliminary study was to present the cost-effectiveness analyses submitted to the National Institute for Health and Care Excellence (NICE) (TA10765) that deemed semaglutide 2.4...
Conclusion: Semaglutide 2.4 mg s.c. injection is a cost-effective therapy compared to D&E alone for patients with obesity and weight-related comorbidities in the UK. Sensitivity and scenario analyses confirm the robustness of the analyses.
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Metformin and Cervical Cancer Risk in Patients with Newly Diagnosed Type 2 Diabetes: A Population-Based Study in Korea - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36604960/
Metformin use in patients with newly diagnosed diabetes was associated with a lower risk of cervical cancer in Korea. Furthermore, a significant association was found between the use of metformin...
Conclusion: Metformin use in patients with newly diagnosed diabetes was associated with a lower risk of cervical cancer in Korea. Furthermore, a significant association was found between the use of metformin and cervical cancer in a dose- and duration-dependent manner and among those over 50 years old.
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Real-world use of once-weekly semaglutide in type 2 diabetes: results from SURE Germany
Source : https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-2007-2061
CC BY-NC-ND 4.0 · Exp Clin Endocrinol Diabetes DOI: 10.1055/a-2007-2061 1 Innere Medizin - Diabetologie und Endokrinologie, Gemeinschaftskrankenhaus Bonn, Bonn, Germany 4 Novo Nordisk Pharma GmbH, Mainz, Germany...
Conclusions: In a real-world population in Germany, patients with type 2 diabetes treated with once-weekly semaglutide experienced clinically significant improvements in glycaemic control and body weight. These results support use of once-weekly semaglutide in routine clinical practice in adult patients with type 2 diabetes in Germany.
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Clinical Insight on Semaglutide for Chronic Weight Management in Adults: Patient Selection and Special Considerations
Intensive lifestyle intervention (ILI) that includes counseling on behavioral, physical activity, and dietary strategies is the first-line treatment for obesity. In clinical research trials, ILI produces losses of 7-8% of...
Conclusions/Relevance: In this paper, we discuss considerations for the selection of individuals who are candidates for semaglutide and special considerations related to the use of this medication. These include its efficacy and safety, as well as its contraindications, potential adverse effects, management of comorbidities and drug...
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Glucagon-like peptide 1-receptor agonists and A1c: Good for the heart but less so for the eyes?
Source : https://www.sciencedirect.com/science/article/abs/pii/S1871402122003137?via=ihub
GLP1-RA decrease cardiovascular events [CE] but may worsen diabetic retinopathy [DR]. * Increase in DR was found in subcutaneous semaglutide >1 year and with decreases in A1c > 1.0%. *...
Conclusions: This meta-analysis may assist in decisions balancing the relative risk (of existing retinopathy) versus benefits (to existing CVD). There should be close collaboration with ophthalmology to grade the baseline degree of retinopathy when initiating and following patients.
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