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The Microbiota and Evolution of Obesity - PubMed

The Microbiota and Evolution of Obesity - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/39673174/

Obesity is a major global concern and is generally attributed to a combination of genetic and environmental factors. Several hypotheses have been proposed to explain the evolutionary origins of obesity...

This review proposes that immune system evolution and pathogen defense (metaflammation), combined with gut microbiota genetics, contribute to obesity's origins, emphasizing a multifactorial, evolutionary and polygenic understanding of the epidemic.

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GLP-1 Therapies in Metabolic and Hormonal Health: ENDO 2025 Insights

At ENDO 2025, Dr. Monica Laronda (Lurie Children’s Hospital, Northwestern University) highlighted emerging research investigating how GLP-1 therapies and rising obesity rates may influence puberty onset, menarche timing, and sex-specific disease expression—particularly in adolescents with high BMI or genetic susceptibility. She also discussed environmental and epigenetic drivers of endocrine disruption and underscored the need to consider sex as a biological variable in metabolic research. Dr. Shellsea Portillo (St. Louis University Hospital) presented retrospective data indicating that GLP-1–associated weight loss significantly improved testosterone levels in obese men with type 2 diabetes, suggesting a possible avenue for further exploration as a non-hormonal strategy for managing obesity-related hypogonadism. Together, these insights underscore GLP-1’s emerging but preliminary role in reproductive and metabolic endocrine health.

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Obesity, white adipose tissue and cancer - PubMed

Obesity, white adipose tissue and cancer - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/39496581/

White adipose tissue (WAT) is crucial for whole-body energy homeostasis and plays an important role in metabolic and hormonal regulation. While healthy WAT undergoes controlled expansion and contraction to meet...

 

Obesity-induced white adipose tissue dysfunction promotes cancer through systemic inflammation, altered metabolism, and tumor microenvironment remodeling, establishing bidirectional interactions that support tumor growth and reveal potential therapeutic targets.

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In a phase 2b study, efruxifermin added to stable GLP-1RA therapy in MASH patients with T2D was safe and reduced hepatic fat fraction by 65% vs. 10% with GLP-1RA alone. It also improved noninvasive fibrosis and metabolic markers without impacting weight loss benefits.

Review the full trial findings here

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Did you know? Statins are linked to a 9–12% increased risk of new-onset diabetes, particularly with long-term, high-dose use and in patients with impaired glucose regulation. Still, their cardiovascular benefits usually outweigh this risk, prompting continued use in most at-risk populations.

Could statins’ effects on insulin release and sensitivity explain their role in glucose abnormalities?

Statins

Could statins’ effects on insulin release and sensitivity explain their role in glucose abnormalities?

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