Caloric Restriction Intervention Alters Specific Circulating Biomarkers of the Senescence-Associated Secretome in Middle-Aged and Older Adults With Obesity and Prediabetes in an 18-Week Randomized Controlled Trial - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37738560/
Cellular senescence is a biological aging process that is exacerbated by obesity and leads to inflammation and age- and obesogenic-driven chronic diseases including type 2 diabetes. Caloric restriction (CR) may...
Caloric restriction in middle-aged adults with obesity and prediabetes significantly alters circulating SASP biomarkers, though T-cell senescence markers remain unchanged, indicating reduced senescent cell burden linked to weight loss.
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Childhood obesity from the genes to the epigenome - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39045266/
The prevalence of obesity and its associated comorbidities has surged dramatically in recent decades. Especially concerning is the increased rate of childhood obesity, resulting in diseases traditionally associated only with...
Obesity's transgenerational inheritance, driven by epigenetic mechanisms from parental obesity, contributes to offspring's increased body weight and long-term cardiometabolic risks, offering insights for improved clinical management and prevention strategies.
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Sarcopenic obesity and osteoporosis: Research progress and hot spots
Source : https://pubmed.ncbi.nlm.nih.gov/39147076/
Sarcopenic obesity (SO) and osteoporosis (OP) are associated with aging and obesity. The pathogenesis of SO is complex, including glucolipid and skeletal muscle metabolic disorders caused by inflammation, insulin resistance,...
Sarcopenic obesity and osteoporosis are interrelated through muscle-lipid metabolism and inflammation. Addressing both conditions requires exploring new therapeutic targets and combining exercise with diet for improved musculoskeletal health.
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Novel hypothalamic pathways for metabolic effects of spexin
Source : https://pubmed.ncbi.nlm.nih.gov/39245191/
One of the main underlying etiologies of type 2 diabetes (T2DM) is insulin resistance, which is most frequently caused by obesity. Notably, the deregulation of adipokine secretion from visceral adiposity...
Spexin's role in regulating energy metabolism and homeostasis, through hypothalamic melanocortin pathways, highlights its potential as a therapeutic target for addressing obesity, insulin resistance, and type 2 diabetes.
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Immunological roles for resistin and related adipokines in obesity-associated tumors - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39232363/
Rationale Obesity is an independent risk factor for the occurrence and development of tumors. Obesity is influenced by signaling of adipokines, which are secreted factors from adipocytes and resident immune...
Resistin and other adipokines play crucial roles in obesity-related tumor development, highlighting their potential as targets for novel anti-tumor strategies to limit tumor growth and manage obesity simultaneously.
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