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Exercise as a Therapeutic Strategy for Obesity: Central and Peripheral Mechanisms - PubMed

Exercise as a Therapeutic Strategy for Obesity: Central and Peripheral Mechanisms - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/39590824/

Obesity is a complex, multifactorial condition involving excessive fat accumulation due to an imbalance between energy intake and expenditure, with its global prevalence steadily rising. This condition significantly increases the...

 

Exercise combats obesity by modulating central nervous system functions and enhancing peripheral metabolic processes, promoting fat oxidation and energy balance; deeper insight into these interactions can improve obesity management strategies.

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Comparative efficacy of exercise, diet and/or pharmacological interventions on BMI, ovulation, and hormonal profile in reproductive-aged women with overweight or obesity: a systematic review and network meta-analysis - PubMed

Comparative efficacy of exercise, diet and/or pharmacological interventions on BMI, ovulation, and hormonal profile in reproductive-aged women with overweight or obesity: a systematic review and network meta-analysis - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/38627233/

Overall, the findings of this network meta-analysis indicate that the combination of exercise, diet, and pharmacological interventions is effective for weight loss, improving ovulation, and normalizing the androgen levels of...

 

Combining exercise, diet, and pharmacological interventions effectively reduces BMI, improves ovulation, and normalizes hormones in overweight women, supporting a comprehensive approach to enhance fertility outcomes.

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Emerging pharmacotherapies for obesity: A systematic review - PubMed

Emerging pharmacotherapies for obesity: A systematic review - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/39952695/

The history of antiobesity pharmacotherapies is marked by disappointments, often entangled with societal pressure promoting weight loss and the prevailing conviction that excess body weight signifies a lack of willpower....

 

This review highlights emerging antiobesity drugs, particularly incretin-based therapies, showing promising weight loss results in phase 2/3 trials, with a need for long-term safety, efficacy, and broader population studies.

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Placental inflammation, oxidative stress, and fetal outcomes in maternal obesity - PubMed

Placental inflammation, oxidative stress, and fetal outcomes in maternal obesity - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/38418281/

The obesity epidemic has led to a growing body of research investigating the consequences of maternal obesity on pregnancy and offspring health. The placenta, traditionally viewed as a passive intermediary...

 

Maternal obesity induces placental inflammation and oxidative stress, disrupting fetal development and increasing offspring disease risk; understanding these mechanisms is key to developing effective intervention strategies.

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ACOG 2025: Redesigning Prenatal Care and Rethinking Cardiovascular Risk in PCOS

At ACOG 2025, experts highlighted innovations in obstetric care and cardiovascular research in PCOS. Dr. Amy Dillmeyer-Klinski, OB-GYN and member of the ACOG Scientific Program Committee, advocated for a modernized, patient-centered prenatal care model incorporating virtual visits and addressing social determinants of health. Dr. Tina Hsieh (Beth Israel Deaconess) presented real-world data suggesting that GLP-1 receptor agonists were associated with reduced arrhythmia and thrombotic events in women with PCOS compared to metformin. While preliminary, these findings may inform future therapeutic directions pending validation from long-term outcome studies..

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