Sarcopenic obesity and health outcomes: An umbrella review of systematic reviews with meta-analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38897937/
Many studies support the idea that sarcopenic obesity (SO) could be considered a potential risk factor for negative health outcomes. These results have been inconsistent, and no umbrella reviews exist...
Sarcopenic obesity may increase risks for cognitive impairment, coronary artery disease, and dyslipidaemia, but evidence is mainly from cross-sectional studies; further research is needed for clear definitions and outcomes.
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Fecal microbiota transplantation alters gut phage communities in a clinical trial for obesity - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38970126/
The Gut Bugs Trial was registered with the Australian New Zealand Clinical Trials Registry (ACTR N12615001351505). Trial protocol: the trial protocol is available at https://bmjopen.bmj.com/content/9/4/e026174 . Video Abstract.
Fecal microbiota transplantation (FMT) significantly alters recipients' phage populations, increasing diversity and variability, and correlates with the engraftment of donor phages and improved microbial diversity.
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The Roles of Obesity and ASB4 in Preeclampsia Pathogenesis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39201703/
Preeclampsia is a complex pregnancy-related hypertensive disorder which poses significant risks for both maternal and fetal health. Preeclampsia affects 5-8% of pregnancies in the United States, causing a significant public...
Preeclampsia, affecting 5-8% of pregnancies, is linked to obesity. ASB4, an E3 ligase, exacerbates preeclampsia-like symptoms in obese mice, with ASB4 gene variants associated with obesity in humans.
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Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota
Source : https://pubmed.ncbi.nlm.nih.gov/38409604/
Emerging evidence suggests that modulation of gut microbiota by dietary fibre may offer solutions for metabolic disorders. In a randomized placebo-controlled crossover design trial (ChiCTR-TTRCC-13003333) in 37 participants with overweight...
Resistant starch supplementation promotes weight loss and improves insulin resistance in overweight individuals by modifying gut microbiota, with Bifidobacterium adolescentis playing a key role in these benefits.
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Dysfunctional Mitochondria Clearance in Situ: Mitophagy in Obesity and Diabetes-Associated Cardiometabolic Diseases
Source : https://pubmed.ncbi.nlm.nih.gov/38356350/
Several mitochondrial dysfunctions in obesity and diabetes include impaired mitochondrial membrane potential, excessive mitochondrial reactive oxygen species generation, reduced mitochondrial DNA, increased mitochondrial Ca2+ flux, and mitochondrial dynamics disorders. Mitophagy,...
Mitochondrial dysfunction and dysregulated mitophagy in obesity and diabetes contribute to heart disorders. Targeted mitophagy interventions may restore mitochondrial function and improve cellular health in these conditions.
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