Obesity and Inflammatory Factors in the Progression of Early-Onset Colorectal Cancer
Source : https://pubmed.ncbi.nlm.nih.gov/38611081/
Metabolic dysfunction associated with obesity leads to a chronic pro-inflammatory state with systemic effects, including the alteration of macrophage metabolism. Tumor-associated macrophages have been linked to the formation of cancer...
Understanding how obesity-related hormones and inflammatory mechanisms contribute to early-onset colorectal cancer can help develop new therapeutic targets and highlight the potential protective role of chemo-preventative agents like aspirin.
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Obesity and body mass index: Past and future considerations in osteoarthritis research
Source : https://pubmed.ncbi.nlm.nih.gov/38354848/
Obesity is an important topic for the osteoarthritis (OA) scientific community. However, the predominant use of body mass index (BMI) to define obesity in OA research is associated with uncertainties...
Future OA research should adopt alternative measures beyond BMI to accurately identify obesity, consider evolving obesity science, and minimize weight stigma to enhance health outcomes for those with or at risk for OA.
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Therapeutic advances in obesity management: an overview of the therapeutic interventions
Source : https://pubmed.ncbi.nlm.nih.gov/38715796/
Obesity has become a global epidemic in the modern world, significantly impacting the global healthcare economy. Lifestyle interventions remain the primary approach to managing obesity, with medical therapy considered a...
The future of obesity management may hinge on personalized medicine, targeting specific components for novel therapeutic agents, while leveraging the efficacy of GLP-1 RAs and bariatric surgery for comprehensive treatment.
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Obesity, heart failure with preserved ejection fraction, and the role of glucagon-like peptide-1 receptor agonists
Source : https://pubmed.ncbi.nlm.nih.gov/38093506/
Heart failure with preserved ejection fraction (HFpEF) has a high prevalence, affecting more than 50% of patients with heart failure. HFpEF is associated with multiple comorbidities, and obesity is one...
GLP-1 receptor agonists show promise for treating obese patients with HFpEF by promoting weight loss and improving metabolic function, but efficacy and safety must be confirmed through clinical trials.
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Obesity-induced blood-brain barrier dysfunction: phenotypes and mechanisms
Source : https://pubmed.ncbi.nlm.nih.gov/38678254/
Obesity, a burgeoning global health issue, is increasingly recognized for its detrimental effects on the central nervous system, particularly concerning the integrity of the blood-brain barrier (BBB). This manuscript delves...
Obesity-induced BBB dysfunction is crucial for addressing neurodegenerative disease risks and developing targeted therapies, emphasizing the need for continued research in this critical area of neurological health.
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