Obesity management for the treatment of type 2 diabetes: emerging evidence and therapeutic approaches
Source : https://pubmed.ncbi.nlm.nih.gov/38903652/
Excess adiposity can contribute to metabolic complications, such as type 2 diabetes mellitus (T2DM), which poses a significant global health burden. Traditionally viewed as a chronic and irreversible condition, T2DM...
Bariatric surgery stands as a highly effective option for managing body weight and T2DM, yielding significant benefits. Yet, its widespread implementation faces scalability challenges, limiting access for many who could potentially benefit. In contrast, GLP-1RAs, and more particularly dual and triple agonists, offer a promising alternative,...
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Insulin resistance assessed by short insulin tolerance test and its association with obesity and insulin resistance-related parameters in humans: A pilot randomized trial
Source : https://pubmed.ncbi.nlm.nih.gov/38905235/
The aim of this study was to examine the association of insulin resistance (evaluated by the short insulin tolerance test [SITT]) with parameters related to obesity and insulin resistance. We...
It did not turn out to be the index test. KITT(iv) was associated with clinical parameters such as VFA, adiponectin, and BCAAs. Of note, KITT(iv) is not affected by endogenous insulin unlike HOMA-IR and, thus, the observed associations notably indicated the pathogenetic link of the examined clinical parameters and insulin resistance. KITT(iv)...
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The effect of a combined lifestyle intervention with and without protein drink on inflammation in older adults with obesity and type 2 diabetes
Source : https://pubmed.ncbi.nlm.nih.gov/38527636/
13 weeks of combined lifestyle intervention, either with or without protein drink, reduced circulating adipokines and anti-inflammatory cytokine IL-1RA, and increased inflammatory ratios TNF-α/IL-10 and TNF-α/IL-1RA in older adults with...
13 weeks of combined lifestyle intervention, either with or without protein drink, reduced circulating adipokines and anti-inflammatory cytokine IL-1RA, and increased inflammatory ratios TNF-α/IL-10 and TNF-α/IL-1RA in older adults with obesity and T2D. Effect on CLIP was inversely related to baseline inflammatory status.
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Mediterranean diet as a strategy for preserving kidney function in patients with coronary heart disease with type 2 diabetes and obesity
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11099022/
Type 2 diabetes mellitus (T2DM) is recognized an independent risk factor for chronic kidney disease (CKD). The precise contribution and differential response to treatment strategies to reduce kidney dysfunction, depending...
Obesity provided an additive effect to T2DM resulting in a more pronounced decline in kidney function compared to T2DM alone when compared to non-diabetics. In patients with concomitant presence of T2DM and obesity, with more metabolic complications, consumption of a Mediterranean diet seemed more beneficial than a low-fat diet in terms of...
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Surveillance of the liver in type 2 diabetes: important but unfeasible?
Source : https://pubmed.ncbi.nlm.nih.gov/38334817/
Fatty liver plays a pivotal role in the pathogenesis of the metabolic syndrome and type 2 diabetes. According to an updated classification, any individual with liver steatosis and one or...
Emerging evidence suggests that fibrosis biomarkers may serve as tools for risk-based targeting of weight-loss interventions and potentially for monitoring response to therapy.
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