Pharmaceutical Therapies for the Treatment of Obesity: A Network Meta-analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37400324/
According to the results of this NMA, semaglutide seems to be an effective treatment option for both men and women, whereas beloranib appears to be particularly effective for women with...
Implications: According to the results of this NMA, semaglutide seems to be an effective treatment option for both men and women, whereas beloranib appears to be particularly effective for women with obesity and overweight, but its production has been stopped since 2016 and is not available.
Share
Beyond Ozempic: brand-new obesity drugs will be cheaper and more effective
Source : https://www.nature.com/articles/d41586-023-02092-9
Hormone mimics offer advantages even beyond those of the potent weight-loss jabs on the market now. Hormone mimics offer advantages even beyond those of the potent weight-loss jabs on the...
Relevance: Two new drugs for treating obesity are on course to become available in the next few years — and they offer advantages beyond those of the highly effective blockbuster drugs already on the market. The first, called orforglipron, is easier to use and to produce, and it will probably be cheaper than existing treatments. The second,...
Share
The Role of GLP1-RAs in Direct Modulation of Lipid Metabolism in Hepatic Tissue as Determined Using In Vitro Models of NAFLD - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37367037/
Glucagon-like peptide 1 receptor agonists (GLP-1RAs) have been shown to improve glucose and lipid homeostasis, promote weight loss, and reduce cardiovascular risk factors. They are a promising therapeutic option for...
Conclusions/Relevance: Most recent clinical trials have suggested the importance of early pharmacologic intervention with GLP-1RAs in alleviating and limiting NAFLD, as well as highlighting the relative scarcity of in vitro studies on semaglutide, indicating the need for further research. However, extra-hepatic factors contribute to the...
Share
Administration errors of compounded semaglutide reported to a poison control center - case series - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37392810/
These three semaglutide cases highlight the potential for patient harm given current practices. Vials of compounded semaglutide do not employ safety features provided by pre-filled manufactured pens and allow for...
Objectives: We aim to increase pharmacists’ and regulatory agencies’ awareness of emerging issues regarding current practices of semaglutide use in the community which has led to increased reports of administration errors and adverse drug events to our regional poison control center.
Share
Conclusions/Relevance: This case highlights the need for access to affirming weight management services for TGD patients pursuing GAS and the role of antiobesity medications in reaching presurgical BMI targets. Further studies should evaluate the needs of TGD patients in weight loss interventions and the effects of weight loss and antiobesity...
Share