Semaglutide-eye-catching results
Source : https://www.wjgnet.com/1948-9358/full/v14/i4/424.htm
Glucagon-like peptide-1 receptor agonists (GLP-1RA) are a class of drugs increasingly used for the treatment of patients with type 2 diabetes mellitus (T2DM), enhancing glucose management while promoting weight loss...
Core Tip: Glucagon-like peptide-1 receptor agonists (GLP-1RAs) benefit patients with type 2 diabetes mellitus in terms of glucose management, weight control, oxidative damage, and prevention of adverse renal and cardiovascular events without increasing the of risk of hypoglycemia. After reviewing the literature to investigate upon such a...
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Combination Therapy of Metformin and p-Coumaric Acid Mitigates Metabolic Dysfunction Associated with Obesity and Non-Alcoholic Fatty Liver Disease in High-Fat Diet Obese C57BL/6 Mice
Source : https://www.sciencedirect.com/science/article/abs/pii/S095528632300102X?via=ihub
Available online 25 April 2023, 109369 Author links open overlay panel, , , , Reza Meshkani 1 Show more Metformin (MET) has been demonstrated to have favorable impact on nonalcoholic...
Conclusions/Relevance: Taken together, these findings indicate that MET combined with PCA can improve NAFLD through decreasing lipid accumulation, inhibiting inflammation and inducing thermogenesis, and adipose tissue browning.
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Cost-effectiveness analysis of five anti-obesity medications from a US payer's perspective - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37088648/
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Conclusion: Compared to other AOM, PpT was lowest cost treatment with nearly identical QALYs with other agents.
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Is retatrutide (LY3437943), a GLP-1, GIP, and glucagon receptor agonist a step forward in the treatment of diabetes and obesity? - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37086147/
The role of stimulating glucagon receptors in the treatment of type 2 diabetes and/or obesity is poorly defined and needs to be clarified. Although retatrutide may be superior to the...
Expert Opinion: The role of stimulating glucagon receptors in the treatment of type 2 diabetes and/or obesity is poorly defined and needs to be clarified. Although retatrutide may be superior to the GLP-1 receptor agonist dulaglutide in reducing plasma glucose and body weight, this is not a meaningful comparison, as another GLP-1 receptor...
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Semaglutide alleviates inflammation-Induced endothelial progenitor cells injury by inhibiting MiR-155 expression in macrophage exosomes
Source : https://www.sciencedirect.com/science/article/pii/S1567576923005179?via=ihub
Macrophage exosomes impair endothelial progenitor cells function after lipopolysaccharide stimulation. * MiR-155 in macrophage exosomes impairs the function of endothelial progenitor cells and causes inflammation. * Semaglutide may protect endothelial...
Conclusions/Relevance: Semaglutide improved the cell viability of EPCs and also inhibited the expression of inflammatory factors in EPCs as well as miR-155 in exosomes. Semaglutide improves the function and inflammatory status of EPCs may via inhibition of LPS-induced macrophage expression of miR-155 in exosomes.
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