Obesity-induced tissue alterations resist weight loss: A mechanistic review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38720199/
Interventions aimed at weight control often have limited effectiveness in combating obesity. This review explores how obesity-induced dysfunction in white (WAT) and brown adipose tissue (BAT), skeletal muscle, and the...
Obesity-induced dysfunction in adipose tissue, muscle, and brain impairs lipolysis, thermogenesis, metabolism, and satiety signaling, collectively hindering effective, sustained weight loss despite common intervention strategies.
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Strategies for minimizing muscle loss during use of incretin-mimetic drugs for treatment of obesity - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39295512/
The rapid and widespread clinical adoption of highly effective incretin-mimetic drugs (IMDs), particularly semaglutide and tirzepatide, for the treatment of obesity has outpaced the updating of clinical practice guidelines. Consequently,...
Rapid adoption of incretin-mimetic drugs for obesity risks muscle loss; combining adequate protein, micronutrients, and resistance training is essential to preserve muscle mass and optimize treatment benefits.
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Obesity: Next game changer of allergic airway diseases? - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40329860/
Obesity and allergic diseases are global health concerns, both of which are seeing an increase in prevalence in recent years. Obesity has been recognised as an important comorbidity in subpopulations...
Obesity exacerbates allergic airway diseases by altering immune endotypes, increasing severity, and reducing treatment response, necessitating weight loss strategies and personalized therapeutic approaches for effective management.
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Obesity, white adipose tissue and cancer - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39496581/
White adipose tissue (WAT) is crucial for whole-body energy homeostasis and plays an important role in metabolic and hormonal regulation. While healthy WAT undergoes controlled expansion and contraction to meet...
Obesity-induced white adipose tissue dysfunction alters metabolism and inflammation, promoting cancer through systemic and local tumor interactions, extracellular remodeling, and reciprocal signaling, highlighting therapeutic intervention opportunities.
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The promise of tirzepatide: A narrative review of metabolic benefits - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/40221292/
Obesity and type 2 diabetes mellites (T2DM) are intertwined epidemics that continue to pose significant challenges to global public health. We aim to review the available evidence on the metabolic...
Tirzepatide offers significant metabolic benefits, inducing substantial weight and fat loss, appetite suppression, improved glycemic and lipid profiles, with manageable side effects, supporting its promise for obesity and T2DM management.
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