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Emerging pharmacotherapies for obesity: A systematic review - PubMed

Emerging pharmacotherapies for obesity: A systematic review - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/39952695/

The history of antiobesity pharmacotherapies is marked by disappointments, often entangled with societal pressure promoting weight loss and the prevailing conviction that excess body weight signifies a lack of willpower....

 

This review highlights emerging antiobesity drugs, particularly incretin-based therapies, showing promising weight loss results in phase 2/3 trials, with a need for long-term safety, efficacy, and broader population studies.

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Placental inflammation, oxidative stress, and fetal outcomes in maternal obesity - PubMed

Placental inflammation, oxidative stress, and fetal outcomes in maternal obesity - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/38418281/

The obesity epidemic has led to a growing body of research investigating the consequences of maternal obesity on pregnancy and offspring health. The placenta, traditionally viewed as a passive intermediary...

 

Maternal obesity induces placental inflammation and oxidative stress, disrupting fetal development and increasing offspring disease risk; understanding these mechanisms is key to developing effective intervention strategies.

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ACOG 2025: Redesigning Prenatal Care and Rethinking Cardiovascular Risk in PCOS

At ACOG 2025, experts highlighted innovations in obstetric care and cardiovascular research in PCOS. Dr. Amy Dillmeyer-Klinski, OB-GYN and member of the ACOG Scientific Program Committee, advocated for a modernized, patient-centered prenatal care model incorporating virtual visits and addressing social determinants of health. Dr. Tina Hsieh (Beth Israel Deaconess) presented real-world data suggesting that GLP-1 receptor agonists were associated with reduced arrhythmia and thrombotic events in women with PCOS compared to metformin. While preliminary, these findings may inform future therapeutic directions pending validation from long-term outcome studies..

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Childhood obesity in relation to risk of dental caries: a cumulative and dose-response systematic review and meta-analysis - PubMed

Childhood obesity in relation to risk of dental caries: a cumulative and dose-response systematic review and meta-analysis - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/39164714/

The findings of this study have significant implications for public health and dental care, suggesting association between BMI and the risk of dental caries in children. This comprehensive meta-analysis is...

 

Higher BMI in children is significantly linked to increased risk of dental caries, especially early childhood caries, with non-linear trends observed; further prospective studies and refined assessments are recommended.

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Childhood obesity from the genes to the epigenome - PubMed

Childhood obesity from the genes to the epigenome - PubMed

Source : https://pubmed.ncbi.nlm.nih.gov/39045266/

The prevalence of obesity and its associated comorbidities has surged dramatically in recent decades. Especially concerning is the increased rate of childhood obesity, resulting in diseases traditionally associated only with...

 

Parental obesity can epigenetically program offspring for obesity and cardiometabolic issues. This review explores maternal and paternal roles, underlying mechanisms, and potential sex-specific transgenerational health impacts.

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