Effects of Metabolic Dysfunction-Associated Steatotic Liver Disease on Bone Density and Fragility Fractures: Associations and Mechanisms - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38740429/
Metabolic dysfunction-associated steatotic liver disease (MASLD) has profound adverse effects on bone health and homeostasis. MASLD appears to be associated with changes in bone mineral density (BMD) and fracture rate....
MASLD impacts bone health, reducing BMD and increasing fragility fractures in adults, especially elderly Asian men, due to disrupted bone remodeling, insulin resistance, inflammation, and comorbidities like obesity and diabetes.
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Diet, exercise, and supplements: what is their role in the management of the metabolic dysfunction-associated steatotic liver disease in children? - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38519764/
Metabolic dysfunction-associated steatotic liver disease (MASLD), previously known as nonalcoholic fatty liver disease (NAFLD), is the main cause of chronic liver disease in children and adolescents. Indeed, epidemiological studies have...
Pediatric MASLD, affecting up to 40% of children with obesity, primarily responds to lifestyle interventions like diet and exercise; studies highlight benefits but lack consensus on optimal approaches, warranting further research.
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Obesity and its impact on female reproductive health: unraveling the connections - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38264286/
In the modern era, the escalating global prevalence of obesity has profound implications on female reproductive health. Obesity, transcending mere lifestyle choices, has evolved into a complex disorder affecting physiological...
Obesity significantly impacts female reproductive health, contributing to conditions like PCOS, menstrual disturbances, and infertility. Weight loss strategies and IVF efficacy are influenced by obesity, involving hormonal and inflammatory disruptions.
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The emergence of obesity in type 1 diabetes - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38092958/
Obesity, a chronic low-grade inflammatory disease represented by multifactorial metabolic dysfunctions, is a significant global health threat for adults and children. The once-held belief that type 1 diabetes is a...
This review discusses the intersection of type 1 diabetes and obesity, highlighting their bidirectional relationship, biopsychosocial impacts, and therapeutic approaches, including exercise, nutrition, pharmacotherapy, and bariatric surgery.
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Appetite- and Weight-Regulating Neuroendocrine Circuitry in Hypothalamic Obesity - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38019584/
Since hypothalamic obesity (HyOb) was first described over 120 years ago by Joseph Babinski and Alfred Fröhlich, advances in molecular genetic laboratory techniques have allowed us to elucidate various components...
This review explores the neuroendocrine physiology of appetite and weight regulation, focusing on hypothalamic obesity (HyOb), its pathophysiology, and the challenges in translating molecular discoveries into effective treatments.
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