At the American Heart Association’s centennial conference, Dr. Amit Khera, Director of Preventive Cardiology and Professor at UT Southwestern Medical Center, and Dr. John L. Sapp, Assistant Dean of Clinical Research at Dalhousie University, presented key findings. Topics included Tirzepatide’s impact on HFpEF and obesity, the comparison of left atrial appendage closure versus anticoagulation for atrial fibrillation, intensive blood pressure control in diabetes, and insights from the VANISH2 trial on ventricular tachycardia. These findings provide healthcare professionals with evidence-based strategies to advance cardiovascular care.
Interventions to prevent obesity in children aged 5 to 11 years old - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38763517/
The body of evidence in this review demonstrates that a range of school-based 'activity' interventions, alone or in combination with dietary interventions, may have a modest beneficial effect on obesity...
This review assessed interventions to prevent obesity in children, finding that dietary, activity, and combined interventions have minimal or moderate effects on BMI and zBMI, with limited evidence on serious adverse events.
Effects of Weight Loss on Key Obesity-Related Biomarkers Linked to the Risk of Endometrial Cancer: A Systematic Review and Meta-Analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/38927903/
Endometrial cancer (EC) includes various histologic types, with estrogen-dependent endometrioid carcinoma being the most common. Obesity significantly increases the risk of developing this type, especially in postmenopausal women, due to...
This review analyzes weight loss interventions (bariatric surgery, pharmacotherapy, lifestyle changes) on obesity-related biomarkers in endometrioid EC, finding significant reductions in proinflammatory markers and hormones, but highlighting study limitations and gaps.
Ceramides-Emerging Biomarkers of Lipotoxicity in Obesity, Diabetes, Cardiovascular Diseases, and Inflammation - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/39329864/
Abnormalities in lipid homeostasis have been associated with many human diseases, and the interrelation between lipotoxicity and cellular dysfunction has received significant attention in the past two decades. Ceramides (Cers)...
Ceramides are bioactive lipids involved in cellular functions like metabolism, inflammation, and apoptosis. Their accumulation contributes to obesity, diabetes, cardiovascular diseases, and inflammation, highlighting their potential as diagnostic tools.
Overweight and obesity in children and adolescents with endocrine disorders - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37712247/
Obesity has become a serious medical condition where many factors can contribute to excess weight gain. The most common type of childhood obesity is simple obesity, which is due to...
Childhood obesity, often simple and environment-driven, can stem from rare endocrine causes. Early detection and treatment of endocrinopathies are crucial for reducing morbidity and reversing obesity-related disturbances.
