Clinical Significance and Management of Low-Level HIV Viremia in the Era of Integrase Strand Transfer Inhibitors
Source : https://pubmed.ncbi.nlm.nih.gov/37990782/
This review aims to assess recent findings to provide a view of the clinical significance and management of low-level HIV viremia in the era of INSTIs.
Integrase strand transfer inhibitor-based therapies could lead to lower low-level viremia over time, thereby leading to more effective virologic control.
Fetal Growth Assessed Via Ultrasound in Relation to Maternal HIV Infection Status and Antiretroviral Regimens
We evaluated fetal growth via repeated ultrasounds and calculated Z-scores for fetal growth measures using Intergrowth-21st standards among women with singleton pregnancies. Adjusted linear mixed models were fit for each...
Fetal growth was lower in women living with HIV (WLHIV) than those not living with HIV early in gestation but similar by the end of gestation. Among WLHIV, fetal growth measures were generally similar across antiretroviral regimens evaluated.
HIV-2 Inhibits HIV-1 Gene Expression Via Two Independent Mechanisms During Cellular Co-Infection
Source : https://pubmed.ncbi.nlm.nih.gov/37991365/
Twenty-five years after the first report that HIV-2 infection can reduce HIV-1-associated pathogenesis in dual-infected patients, the mechanisms are still not well understood. We explored these mechanisms in cell culture...
Under specific conditions, HIV-2 inhibits HIV-1 through 2 distinct mechanisms, a broad-spectrum interferon response and an HIV-1-specific inhibition conferred by the HIV-2 TAR.
Hepatitis Delta in HIV/Hepatitis B Coinfection: a Call for Action
Source : https://pubmed.ncbi.nlm.nih.gov/37968830/
Hepatitis delta in HIV/hepatitis B coinfection: a call for action
In people living with HIV infection who are at a particularly high risk of liver disease-related complications, in the presence of underlying hepatitis B/D virus coinfection, hepatitis D virus represents a frequently underdiagnosed critical health issue that needs more attention and research.
Pilot Randomized Controlled Trial of Game Plan for PrEP: a Brief, Web and Text Message Intervention to Help Sexual Minority Men Adhere to PrEP and Reduce Their Alcohol Use
Source : https://link.springer.com/article/10.1007/s10461-023-04223-9
Suboptimal adherence to oral PrEP medications, particularly among younger sexual minority men (SMM), continues to be a key barrier to achieving more substantial declines in new HIV infections. Although variety...
This pilot study explored whether the Game Plan for PrEP, a brief, web-based and text messaging intervention, helped promote PrEP persistence and adherence and reduced condomless sex and alcohol use.