Ex Vivo Rectal Tissue Infection With HIV-1 to Assess Time to Protection Following Oral PrEP With TDF/FTC (a Sub-Study of the ANRS PREVENIR Study)
Participants from the ANRS PREVENIR study (NCT03113123) were offered this sub-study after a 14-day wash-out. We used an ex vivo model to evaluate rectal tissue HIV-1 susceptibility before and after...
Oral tenofovir disoproxil and emtricitabine provided similar protection against HIV-1 infection of rectal tissue 2 hours after a double dose or 7 days of a daily dose.
Global, Regional, and Country-Level Coverage of Testing And Treatment for HIV and Hepatitis C Infection Among People Who Inject Drugs: a Systematic Review
Source : https://pubmed.ncbi.nlm.nih.gov/37973339/
Australian National Health and Medical Research Council and UK National Institute for Health and Care Research Health Protection Research Unit in Behavioural Science and Evaluation.
The findings of this study show the crucial need for producing quality data on HIV and HCV care coverage among people who inject drugs at a country level.
Current ART, Determinants for Virologic Failure and Implications for HIV Drug Resistance: an Umbrella Review
Source : https://aidsrestherapy.biomedcentral.com/articles/10.1186/s12981-023-00572-6
The purpose of this study is to investigate the incidence of determinants for virologic failure and to identify predisposing factors to enhance treatment efficacy. Tackling this global public health issue...
This article highlights several primary causes of treatment failure, including poor adherence to medication, low CD4 T-cell counts, high viral levels, and specific types of regimens used.
A Qualitative Exploration of Perceived Medication Adherence Determinants Conducted Among Older Adults With HIV and Type 2 Diabetes Mellitus
Identifying and comparing perceived determinants of medication adherence for HIV and, separately, for T2DM, and exploring how participants prioritize conditions...
Although many determinants of medication adherence for T2DM may be similar to those for HIV infection, HCPs should explore the possibility that motivations to take medications may differ by condition.
Virologic Outcomes of Antiretroviral Therapy in Patients With HIV-1 Following Bariatric Surgery: a Case Series and Review of the Literature
Source : https://pubmed.ncbi.nlm.nih.gov/37933455/
There were no deleterious effects on HIV progression for PLWH that underwent bariatric surgery. More prospective research is required to validate the effects of bariatric surgery on immunologic and virologic...
In this case series, no deleterious effects on HIV progression were seen for people living with HIV who underwent bariatric surgery.