Mpox disease progression occurred in 3 people living with HIV infection (PWH; 5.4%) in the early tecovirimat group and in 15 PWH (26.8%) in the late or no tecovirimat group.
Racial Inequities in HIV Incidence Among Men Who Have Sex With Men Prior to and Amidst an Ending the HIV Epidemic Initiative
Source : https://pubmed.ncbi.nlm.nih.gov/38265417/
Despite decreases in HIV incidence among MSM, racial inequities were exacerbated over time. Addressing structural factors that impact racial inequities in risk of HIV should undergird EHE initiatives.
Black and Latino men who have sex with men (MSM) seroconverted at significantly higher rates than White MSM in the same age groups and neighborhood poverty level.
Development and Validation of an Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry Method to Quantify Antiretroviral Drug Concentrations in Human Plasma for Therapeutic Monitoring
Source : https://pubmed.ncbi.nlm.nih.gov/38198884/
Antiretroviral therapy (ART) is highly effective for the treatment of HIV-1 infection. ART previously consisted of concomitant administration of many drugs, multiple times per day. Currently, ART generally consists of...
A team of researchers developed and validated a highly selective, ultra-performance liquid chromatography-tandem mass spectrometry method for the simultaneous quantification of abacavir, bictegravir, cabotegravir, dolutegravir, doravirine, emtricitabine, lamivudine, raltegravir, and tenofovir in human plasma.
Archived multiclass drug resistance might complicate the preservation of HIV RNA suppression.
Divergent Effects of the Antiretroviral Drugs, Dolutegravir, Tenofovir Alafenamide, and Tenofovir Disoproxil Fumarate, on Human Adipocyte Function
Source : https://www.sciencedirect.com/science/article/pii/S0006295223006032?via=ihub
Combined antiretroviral therapy (cART) has been associated with increased body weight accompanied by metabolic alterations in people living with human...
Tenofovir alafenamide and tenofovir disoproxil fumarate both had mild effects on differentiating/differentiated adipocytes but exacerbated some of the dolutegravir effects on cell stress, fibrosis, and hypoxia in human adipocytes.