Real-world effectiveness of COVID-19 vaccines and anti-SARS-CoV-2 monoclonal antibodies against postacute sequelae of SARS-CoV-2: analysis of a COVID-19 observational registry for a diverse US metropolitan population
Source : https://bmjopen.bmj.com/content/13/4/e067611
Objectives We evaluated the effectiveness of COVID-19 vaccines and monoclonal antibodies (mAbs) against postacute sequelae of SARS-CoV-2 infection (PASC). Design and setting A retrospective cohort study using a COVID-19 specific,...
Conclusion: Although both COVID-19 vaccines and mAbs decreased the likelihood of PASC, vaccination remains the most effective tool for the prevention of long-term consequences of COVID-19.
Interpretation: A 1 + 1 PCV schedule greatly reduces vaccine-type carriage and is likely to generate substantial herd protection and provide some degree of individual protection during the first year of life. Such a schedule is suitable for mature PCV programmes or for introduction in conjunction with a comprehensive catch-up campaign,...
The evolution of colistin resistance increases bacterial resistance to host antimicrobial peptides and virulence
Source : https://doi.org/10.7554/eLife.84395
Pramod K Jangir , Craig R MacLean , Department of Biology, University of Oxford, United Kingdom; Synthetic and Systems Biology Unit, Biological Research Centre, Eötvös Loránd Research Network, Hungary; Doctoral...
Antimicrobial peptides (AMPs) are a class of antibiotics that are inspired by natural components of innate immunity, which raises the specter of bacteria becoming resistant to both. Jangir et al. test this idea and find compelling evidence that a plasmid that encodes resistance to the AMP colistin also increases resistance to AMPs produced by...
Highlights:
•Patients with MIS-C and COVID-19 have distinct cell injury and host response profiles
•Patients with MIS-C and COVID-19 have elevated solid organ derived cell-free DNA
•Patients with MIS-C have increased endothelial and neuronal derived cell-free RNA
•Cell-free and whole blood RNA provide complementary...
Highlights:
•1,449 plasma proteins are altered by COVID-19 infection, ventilation, or death
•Distinct prognostic models for ventilation and death after COVID-19 infection
•Altered proteins link to Alzheimer’s and coronary artery disease pathways
•Eight proteins are potentially causal for COVID-19 infection