Conclusions and Relevance: In this comparative effectiveness cohort study among adult patients with septic shock who began hydrocortisone treatment, the addition of fludrocortisone was superior to hydrocortisone alone.
COVID-19 and Sickle Cell Disease: Two Independent Risk Factors for Venous Thromboembolism
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been widely documented as a multi-systemic illness and associated with an increased incidence of thromboses. Likewise,...
We report on current literature to date describing rates of VTE in SCD-COVID-19 patients and outline prospective areas of research to further understand the possible synergistic influence of coagulopathy in these patients. The association between SCD and COVID-19 remains a largely under-researched area of coagulopathy in current hematology...
Connecting the Dots: The Interplay Between Stroke and the Gut-Brain Axis
This article discusses the interplay between the gut-brain axis and stroke, a multifaceted neurological disorder that affects millions of people worldwide. The gut-brain axis is a bidirectional communication network linking...
Research on animals has shown that modifying the gut microbiota can impact the results of a stroke. Germ-free mice displayed improved neurological function and decreased infarct volumes, indicating a positive effect. Furthermore, studies in stroke patients have shown alterations in the gut microbiota composition, indicating that targeting...
Germline-encoded amino acid-binding motifs drive immunodominant public antibody responses - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37023193/
Despite the vast diversity of the antibody repertoire, infected individuals often mount antibody responses to precisely the same epitopes within antigens. The immunological mechanisms underpinning this phenomenon remain unknown. By...
Conclusion: Recurrent antibody responses to immunodominant public epitopes are a general feature of humoral immunity. We propose that they are driven by GRAB motifs, a germline-encoded component of the architecture of the antibody repertoire that predisposes antibodies to recognize particular structures and thus influences epitope selection...
Highlights:
•1,449 plasma proteins are altered by COVID-19 infection, ventilation, or death
•Distinct prognostic models for ventilation and death after COVID-19 infection
•Altered proteins link to Alzheimer’s and coronary artery disease pathways
•Eight proteins are potentially causal for COVID-19 infection