Germline-encoded amino acid-binding motifs drive immunodominant public antibody responses - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37023193/
Despite the vast diversity of the antibody repertoire, infected individuals often mount antibody responses to precisely the same epitopes within antigens. The immunological mechanisms underpinning this phenomenon remain unknown. By...
Conclusion: Recurrent antibody responses to immunodominant public epitopes are a general feature of humoral immunity. We propose that they are driven by GRAB motifs, a germline-encoded component of the architecture of the antibody repertoire that predisposes antibodies to recognize particular structures and thus influences epitope selection...
Highlights:
•1,449 plasma proteins are altered by COVID-19 infection, ventilation, or death
•Distinct prognostic models for ventilation and death after COVID-19 infection
•Altered proteins link to Alzheimer’s and coronary artery disease pathways
•Eight proteins are potentially causal for COVID-19 infection
A multi-organoid platform identifies CIART as a key factor for SARS-CoV-2 infection - Nature Cell Biology
Source : https://www.nature.com/articles/s41556-023-01095-y
COVID-19 is a systemic disease involving multiple organs. We previously established a platform to derive organoids and cells from human pluripotent stem cells to model SARS-CoV-2 infection and perform drug...
Lung airway organoids, lung alveolar organoids and cardiomyocytes derived from isogenic CIART−/− human pluripotent stem cells were significantly resistant to SARS-CoV-2 infection, independently of viral entry. Single-cell RNA-sequencing analysis further validated the decreased levels of SARS-CoV-2 infection in ciliated-like cells of lung...
Assessing and Reassessing the Association of Comorbidities and Coinfections in COVID-19 Patients
Coronavirus disease 2019 (COVID-19) has posed an enormous global health and economic burden. To date, 324 million confirmed cases and over 5.5 million deaths have been reported. Several studies have...
There was a statistically significant difference in the prevalent comorbidities observed in patients coinfected with Staphylococcus aureus and COVID-19 and a statistically non-significant difference in the prevalent comorbidities in patients coinfected with Mycoplasma pneumoniae and COVID-19 as compared to similar infections in non-COVID-19...
Respiratory Syncytial Virus: A Comprehensive Review of Transmission, Pathophysiology, and Manifestation
With an increasing global incidence in children younger than the age of five, respiratory syncytial virus (RSV) is one of the most common viral respiratory infections worldwide. Despite the increasing...
The length of viral shedding also differs depending on the severity of the infection, who is infected, and the underlying immune status of an individual. Currently, there is no definitive treatment for RSV; however, supportive therapy is considered the mainstay treatment. Some pharmaceutical treatments such as ribavirin have been...