Acute Phrenic Neuropathy and Diaphragmatic Dysfunction as a Complication of COVID-19: A Report of Four Cases
Among the neurological manifestations associated with coronavirus disease 2019 (COVID-19), neuropathies are rare. They have been associated with prolonged prostration and metabolic failure in a seriously ill patient. We present...
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We confirm and extend the neurological manifestations of COVID-19, the impact on the neuromuscular dysfunction of the diaphragm, and its consequences such as the difficulty of weaning from mechanical ventilation.
Highlights
- A DNA-biosensor was integrated in a microfluidic device for direct SARS-CoV-2 RNA detection in human saliva samples.
- The DNA/RNA duplex was detected via fluorescence measurements, resulting in a limit of detection of 10 aM.
- The specificity was validated over saliva samples containing MERS coronavirus.
- The designed sensing platform...
Analysis of length of stay and treatment emergent complications in hospitalized myasthenia gravis patients with exacerbation - BMC Neurology
Introduction AIMS Myasthenia Gravis (MG) is an autoimmune neuromuscular disease in which patients suffer from recurrent exacerbation. There are insufficient data measuring the effects of the resources employed before and...
Discussion: Plasmapheresis, intubation, and male sex were associated with increased LOS in acute MG exacerbation. Intubation appears to be the strongest predictor of LOS. Those with previous thymectomy had shorter hospital stays. The role of thymectomy in the acute setting merits further analysis.
A single-shot ChAd3-MARV vaccine confers rapid and durable protection against Marburg virus in nonhuman primates - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36516269/
Marburg virus (MARV) causes a severe hemorrhagic fever disease in primates with mortality rates in humans of up to 90%. MARV has been identified as a category A bioterrorism agent...
Protective immunity was achieved within 7 days of vaccination and was maintained through 1 year after vaccination. Antigen-specific antibodies were an immune correlate of protection in the acute challenge model, and their concentration was predictive of protection. These results demonstrate that a single-shot ChAd3-MARV vaccine generated a...
The time between vaccination and infection impacts immunity against SARS-CoV-2 variants
Source : https://doi.org/10.1101/2023.01.02.23284120
As the COVID-19 pandemic continues, long-term immunity against SARS-CoV-2 will be globally important. Official weekly cases have not dropped below 2 million since September of 2020, and continued emergence of...
These results indicate that anti-SARS-CoV-2 antibody responses undergo continual maturation following primary exposure by either vaccination or infection for at least 400 days after last antigen exposure. We show that neutralizing antibody responses improved upon secondary boosting with greater impact seen after extended intervals. Our findings...