A Sharp Rise in Autoimmune Encephalitis in the COVID-19 Era: A Case Series - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36755772/
This observation has important implications: (1) We may be entering an era of heightened autoimmune encephalitis. (2) These occurrences may be post-infectious in nature at this point of the pandemic....
Conclusions: This observation has important implications: (1) We may be entering an era of heightened autoimmune encephalitis. (2) These occurrences may be post-infectious in nature at this point of the pandemic. (3) Mostly GAD and VGKC antibodies have been identified (10 of them), which may point toward a new direction of research from a...
New compound inhibits influenza virus replication
Source : https://www.uni-bonn.de/en/news/016-2023
To replicate, viruses need a host cell. There they introduce their genetic information in the form of the nucleic acids DNA or RNA. These molecular blueprints are used in the...
The team led by Prof. Hiroki Kato from the Institute of Cardiovascular Immunology at the University Hospital Bonn has identified a compound that inhibits the body's own methyltransferase MTr1, thereby limiting the replication of influenza viruses.
Exploring immunodominant epitopes of SARS-CoV-2 nucleocapsid protein as a biomarker of exposure - TittlePress
Source : https://tittlepress.com/health/2309794/
The nucleocapsid protein (N protein) of SARS-CoV-2 is undeniably a powerful target for the development of diagnostic tools...
Conclusion: The N2-specific IgG titers in post-COVID-19 samples demonstrated the potential of N protein as an exposure biomarker, particularly in sero-surveillance studies.
Biomonitoring of Indoor Air Fungal or Chemical Toxins with Caenorhabditis elegans nematodes
Source : https://doi.org/10.3390/pathogens12020161
Bad indoor air quality due to toxins and other impurities can have a negative impact on human well-being, working capacity and health. Therefore, reliable methods to monitor the health risks...
Liquid-based or airborne exposure of nematodes to mycotoxins, chemical agents or damaged building materials reproducibly resulted in time- and dose-dependent fluorescent responses, which could be quantitated by either microscopy or spectrometry. Thus, the C. elegans nematodes present an easy, ethically acceptable and comprehensive in vivo model...
Susceptibility of Fat Tissue to SARS-CoV-2 Infection in Female hACE2 Mouse Model
Source : https://doi.org/10.3390/ijms24021314
The coronavirus disease (COVID-19) is a highly contagious viral illness caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). COVID-19 has had a catastrophic effect globally causing millions of deaths worldwide...
Our study revealed for the first time that: (a) viral loads in adipose tissue and the lungs differ between males and females in hACE2 mice; (b) an inverse relationship exists between the viral loads in the lungs and adipose tissue, and it differs between males and females; and (c) CoV-2 infection alters immune signaling and cell death signaling...