SARS-CoV-2 Spike triggers barrier dysfunction and vascular leak via integrins and TGF-β signaling - Nature Communications
Source : https://www.nature.com/articles/s41467-022-34910-5
Severe COVID-19 is associated with epithelial and endothelial barrier dysfunction, however, the molecular pathways resulting in endothelial barrier dysfunction and vascular leakage are only sparsely understood. Here, Biering et al....
Our findings offer mechanistic insight into SARS-CoV-2-triggered vascular leak, providing a starting point for development of therapies targeting COVID-19.
Highlights:
- Potent main protease inhibitors, which block SARS-CoV-2 infection, were developed
- Our strategy adopted fluorine scan and amide surrogate replacement in molecules
- The antiviral activity of the top compound is higher than that of Nirmatrelvir
- Some compounds have remarkably preferable pharmacokinetics in mice
Study reveals recommended anticoagulant therapy for COVID patients
The AustralaSian COVID-19 Trial (ASCOT) has pinpointed the most efficient level of blood thinning treatment needed for patients hospitalised with COVID-19, in a study published in the New England Journal...
In an international study, the ASCOT team conducted a randomised clinical trial to test different levels of anticoagulation (or blood thinning) in more than 1,500 patients in Australia, New Zealand, India and Nepal. They found that an intermediate level of anticoagulation had an 86% probability of being better than low dose anticoagulation. A...
Impact of SARS-CoV-2 vaccination on systemic immune responses in people living with HIV
Source : https://www.frontiersin.org/articles/10.3389/fimmu.2022.1049070/full
Despite the development of vaccines, which protect healthy people from severe and life-threatening Covid-19, the immunological responses of people with secondary immunodeficiencies to these vaccines remain incompletely understood. Here, we...
Our data demonstrate that despite the lower CD4 T cell counts SARS-CoV-2 vaccination results in potent cellular immune responses in PLWH. However, the reduced humoral response also provides strong evidence to consider PLWH as vulnerable group and suggests subsequent vaccinations being required to enhance their protection against COVID-19.
Rapid Resolution of Post-COVID-19 Inflammatory Syndrome in an Adult With Targeted Inhibition of Interleukin-1B
Multisystem inflammatory syndrome (MIS) is a severe inflammatory response that occurs days to weeks following the infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus...
We present a case of an adult patient who had a severe inflammatory state following COVID-19 infection, who was treated with IL-1 antagonist therapy with a successful outcome.