Study reveals recommended anticoagulant therapy for COVID patients
The AustralaSian COVID-19 Trial (ASCOT) has pinpointed the most efficient level of blood thinning treatment needed for patients hospitalised with COVID-19, in a study published in the New England Journal...
In an international study, the ASCOT team conducted a randomised clinical trial to test different levels of anticoagulation (or blood thinning) in more than 1,500 patients in Australia, New Zealand, India and Nepal. They found that an intermediate level of anticoagulation had an 86% probability of being better than low dose anticoagulation. A...
Impact of SARS-CoV-2 vaccination on systemic immune responses in people living with HIV
Source : https://www.frontiersin.org/articles/10.3389/fimmu.2022.1049070/full
Despite the development of vaccines, which protect healthy people from severe and life-threatening Covid-19, the immunological responses of people with secondary immunodeficiencies to these vaccines remain incompletely understood. Here, we...
Our data demonstrate that despite the lower CD4 T cell counts SARS-CoV-2 vaccination results in potent cellular immune responses in PLWH. However, the reduced humoral response also provides strong evidence to consider PLWH as vulnerable group and suggests subsequent vaccinations being required to enhance their protection against COVID-19.
Rapid Resolution of Post-COVID-19 Inflammatory Syndrome in an Adult With Targeted Inhibition of Interleukin-1B
Multisystem inflammatory syndrome (MIS) is a severe inflammatory response that occurs days to weeks following the infection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus...
We present a case of an adult patient who had a severe inflammatory state following COVID-19 infection, who was treated with IL-1 antagonist therapy with a successful outcome.
COVID-19 and Acute Neurologic Complications in Children
Source : https://doi.org/10.1542/peds.2022-058167
James W. Antoon, Matt Hall, Leigh M. Howard, Alison Herndon, Katherine L. Freundlich, Carlos G. Grijalva, Derek J. Williams; COVID-19 and Acute Neurologic Complications in Children. Pediatrics November 2022; 150...
Conclusions: Neurologic complications are common in children hospitalized with COVID-19 and are associated with worse hospital outcomes. Our findings emphasize the importance of COVID-19 immunization in children, especially in high-risk populations, such as those with neurologic comorbidity.
Mutations in SARS-CoV-2 spike protein impair epitope-specific CD4+ T cell recognition - Nature Immunology
Source : https://www.nature.com/articles/s41590-022-01351-7
Based on the identification of CD4+ T cell clones specific for distinct epitopes in the SARS-CoV-2 proteins, Long and colleagues characterize how mutations in these epitopes lead to loss of...
Our results indicated that broad targeting of epitopes by CD4 T cells likely limits evasion by current VOCs. However, continued genomic surveillance is vital to identify new mutations able to evade CD4 T cell immunity.