Evolution of Mood Symptomatology Through the COVID-19 Pandemic: Findings From the CovidSense Longitudinal Study
Background The severe acute respiratory syndrome coronavirus 2 global pandemic, with its associated coronavirus disease 2019 (COVID-19) illness, has led to significant mental, physical, social, and economic hardships. Physical distancing,...
Conclusions:The effects of pandemic-related chronic stress were predominant in young adults and individuals with pre-existing mental and medical conditions regardless of whether they had acquired COVID-19 or not. These results point to the possibility of allocating preventive as well as treatment resources based on vulnerability.
SARS-CoV-2 disrupts respiratory vascular barriers by suppressing Claudin-5 expression
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9491726/
Rina Hashimoto, Formal analysis, Investigation, Methodology, Validation, Writing - original draft, 1 , † Junya Takahashi, Formal analysis, Investigation, Validation, Visualization, Writing - original draft, Writing - review & editing,...
We concluded that the down-regulation of CLDN5 expression is a pivotal mechanism for SARS-CoV-2–induced endothelial barrier disruption in respiratory organs and that inducing CLDN5 expression is a therapeutic strategy against COVID-19.
Test predicts which COVID-19 patients will grow worse, Stanford Medicine study find
Elevated virus levels in hospitalized COVID-19 patients' blood predicts worsening respiratory symptoms and suggests ongoing viral replication in later disease stages, Stanford Medicine-led study says. - By Krista Conger A...
The test measures patient blood levels of a protein on the virus that causes COVID-19. High levels of the protein correlated strongly with an increased need for respiratory support five days later, regardless of the patient’s disease severity when the test was conducted, the researchers found. People whose levels were high were also likely to...
Role for N-glycans and calnexin-calreticulin chaperones in SARS-CoV-2 Spike maturation and viral infectivity - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36149962/
Functional and epidemiological data suggest that N -linked glycans on the SARS-CoV-2 Spike protein may contribute to viral infectivity. To investigate this, we created a panel of N-to-Q mutations at...
In contrast, glycan mutations had a relatively minor effect on cell surface expression of Spike, ACE2 binding, and syncytia formation. A similar dichotomy in function was observed when virus was produced in host cells lacking ER chaperones, calnexin and calreticulin. Here, while both chaperones regulated pseudovirus function, only VLPs produced...
COVID-19 and Genitourinary Tract: A Retrospective Study in the Tertiary Care Center
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9393072/
Monitoring Editor: Alexander Muacevic and John R Adler Introduction COVID-19 pandemic has spread across the globe in the last two years and COVID-19 pneumonia is its typical presentation. Coronavirus (SARS-CoV-2)...
Conclusions: COVID-19 patients do have the chance of developing the involvement of the urinary tract and male genital system and the clinicians should be aware of this so that they can manage these patients accordingly.