REVEALR-Based Genotyping of SARS-CoV-2 Variants of Concern in Clinical Samples
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9236216/
The SARS-CoV-2 virus has evolved into new strains that increase viral transmissibility and reduce vaccine protection. The rapid circulation of these more harmful strains across the globe has created a...
Here, we design REVEALR into a novel genotyping assay that detects single-base mismatches corresponding to each of the major SARS-CoV-2 strains found in the United States. Of 34 sequence-verified patient samples collected in early, mid, and late 2021 at the UCI Medical Center in Orange, California, REVEALR identified the correct variant...
Thermal stabilization of diverse biologics using reversible hydrogels - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35930644/
Improving the thermal stability of biologics, including vaccines, is critical to reduce the economic costs and health risks associated with the cold chain. Here, we designed a versatile, safe, and...
Our data support a generalized protection mechanism for the thermal stabilization of diverse biologics using direct encapsulation in reversible hydrogels. Furthermore, preliminary toxicology data suggest that the components of our hydrogel are safe for in vivo use. Our reversible hydrogel platform offers a simple material solution to mitigate...
SARS-CoV-2 BA.5 vaccine breakthrough risk and severity compared with BA.2: a case-case and cohort study using Electronic Health Records in Portugal
Source : https://doi.org/10.1101/2022.07.25.22277996
Background In a context of multiple Omicron lineages circulation, it is relevant to clarify the effect of vaccination and previous infections on the risk of infection and severe post-infection outcomes.
Interpretation: This study shows that the SARS-CoV-2 Omicron BA.5 lineage is associated with higher odds of reinfection compared with Omicron BA.2, regardless of the vaccination status.
Breakthrough SARS-CoV-2 infections in immune mediated disease patients undergoing B cell depleting therapy: A retrospective cohort analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35791921/
doi: 10.1002/art.42287. Online ahead of print. 1 Department of Rheumatic and Immunologic Diseases, Cleveland Clinic. 2 Mellen Center for Multiple Sclerosis Treatment and Research, Cleveland Clinic. 3 Department of Dermatology,...
Conclusions: IMIDs patients on BCDT regardless of vaccine status appear vulnerable to infection with SARS-CoV-2 and are frequently associated with severe outcomes. Outpatient use of anti-SARS-CoV-2 monoclonal antibody therapy appeared to be associated with enhanced clinical outcomes.
Association of periodic fasting with lower severity of COVID-19 outcomes in the SARS-CoV-2 prevaccine era: an observational cohort from the INSPIRE registry
Source : https://nutrition.bmj.com/content/early/2022/06/30/bmjnph-2022-000462
Objectives Intermittent fasting boosts some host defence mechanisms while modulating the inflammatory response. Lower-frequency fasting is associated with greater survival and lower risk from COVID-19-related comorbidities. This study evaluated associations...
Conclusions: Routine periodic fasting was associated with a lower risk of hospitalisation or mortality in patients with COVID-19. Fasting may be a complementary therapy to vaccination that could provide immune support and hyperinflammation control during and beyond the pandemic.