Poxviruses package viral redox proteins in lateral bodies and modulate the host oxidative response
Source : https://doi.org/10.1371/journal.ppat.1010614
Author summary Vaccinia virus is the prototype member of the Poxviridae family, whose members include monkeypox and variola virus, the causative agent of smallpox. All poxvirus particles, including vaccinia, are...
Using targeted repression and/or deletion viruses we found that deletion of individual LB-redox proteins was insufficient for host redox modulation suggesting there may be functional redundancy. In addition to defining the spatial proteotype of VACV LBs, these findings implicate poxvirus redox proteins as potential modulators of host oxidative...
Transient Global Amnesia Related to the Third Coronavirus Disease-19 (COVID-19) Vaccination
We present a case report of transient global amnesia (TGA) after vaccinating the third dose of coronavirus disease-19 (COVID-19). A 65-year-old Japanese woman presented with TGA after her third vaccination,...
Conclusions: We experienced the case with TGA after the third COVID-19 vaccination. A 65-year-old Japanese woman showed TGA after her third vaccination, which spontaneously resolved. This article aims to facilitate the clinicians’ understanding that TGA could occur after vaccination in the COVID-19 global outbreak. We should be careful of...
Interpretation: Vaccination against COVID-19 in children aged 5–11 years in Italy showed a lower effectiveness in preventing SARS-CoV-2 infection and severe COVID-19 than in individuals aged 12 years and older. Effectiveness against infection appears to decrease after completion of the current primary vaccination cycle.
Admission Hyperglycemia as a Predictor of COVID-19 Pneumonia, Cytokine Release Syndrome Progression, and Clinical Outcomes in a Tertiary Care Hospital
Introduction Diabetes and coronavirus disease 2019 (COVID-19) are interrelated. The presence of hyperglycemia per se during COVID-19 infection regardless of diabetes status has been associated with poor prognosis and increased...
Conclusions: Admission hyperglycemia was associated with an increased risk of progression to critical condition in patients hospitalized with COVID-19 independent of the history of diabetes. Therefore, it should not be overlooked but instead should be detected and appropriately treated to improve outcomes. In addition, post-COVID-19 care should...
New COVID-19 Rapid-test Technology Performs PCR Faster than Similar Tests on the Market
Newswise - New York, NY-July 25, 2022-For more than 30 years, polymerase chain reaction (PCR) has been the gold standard in molecular diagnostic testing, detecting genetic material, such as those...
Sample-to-result workflow of RT-qPCR for rapid detection of SARS-CoV-2, including simple extraction-free sample preparation using a custom cartridge. Results are achieved in 23 minutes of thermocycling, facilitated by plasmonic heating of gold nanoparticles and multiplexed fluorescence monitoring in real-time.