Pathophysiological pathway differences in children who present with COVID-19 ARDS compared to COVID -19 induced MIS-C - Nature Communications
COVID-19 has infected more than 275 million worldwide (at the beginning of 2022). Children appear less susceptible to COVID-19 and present with milder symptoms. Cases of children with COVID-19 developing...
Complement and coagulation activation are implicated in these clinical phenotypes, however there was significant contribution of FcGR and BCR activation in MIS-C and scavenging of haem and retinoid metabolism in COVID-19 ARDS. We show global proteomic differences in MIS-C and COVID-ARDS, although both show complement and coagulation...
The Mysterious Risk of Arterial Thrombosis With COVID-19: A Case Series and Systematic Review of Acute Limb Ischaemia
Introduction: Coronavirus disease 2019 (COVID-19) generates a cytokine storm that predisposes patients to systemic complications including arterial thrombosis (AT) and acute limb ischaemia (ALI). This study reviews our understanding of...
Conclusions: The incidence of AT within the vascular surgery territory in COVID-19 patients is low; however, it is associated with poor 30-day AFS. A computed tomography angiography protocol including the entire major vessels may be indicated in COVID-19 patients.
Risks and burdens of incident diabetes in long COVID: a cohort study
Source : https://www.thelancet.com/journals/landia/article/PIIS2213-8587(22)00044-4/fulltext
In the post-acute phase, we report increased risks and 12-month burdens of incident diabetes and antihyperglycaemic use in people with COVID-19 compared with a contemporary control group of people who...
Interpretation: In the post-acute phase, we report increased risks and 12-month burdens of incident diabetes and antihyperglycaemic use in people with COVID-19 compared with a contemporary control group of people who were enrolled during the same period and had not contracted SARS-CoV-2, and a historical control group from a pre-pandemic era....
Clinical Study Suggests SaNOtize Nitric Oxide Nasal Spray Is Effective at Preventing COVID-19 after High-Risk Exposure
VANCOUVER, British Columbia--()--SaNOtize Research and Development ("SaNOtize") today announced results from a retrospective clinical study assessing the efficacy of nitric oxide releasing nasal spray (NONS™) in preventing COVID-19 infection after...
“Given the rate at which COVID-19 continues to mutate, and the consensus that it will soon be endemic, we need to expand the tools at our disposal to protect against it,” said Chris Miller, PhD, Chief Scientific Officer and co-founder of SaNOtize. “The mounting evidence for NONS is promising, as it suggests a safe and effective tool in...
A glucose-like metabolite deficient in diabetes inhibits cellular entry of SARS-CoV-2 - Nature Metabolism
Source : https://www.nature.com/articles/s42255-022-00567-z
The severity and mortality of COVID-19 are associated with pre-existing medical comorbidities such as diabetes mellitus. However, the underlying causes for increased susceptibility to viral infection in patients with diabetes...
Our results reveal a mechanism that contributes to COVID-19 pathogenesis in the diabetic population and suggest that 1,5-AG supplementation may be beneficial to diabetic patients against severe COVID-19.