Lipoprotein(a) concentrations in acute myocardial infarction patients are not indicative of levels at six month follow-up
Source : https://academic.oup.com/ehjopen/article/3/2/oead035/7107070?login=false
Lipoprotein(a) [Lp(a)] is a low-density lipoprotein like particle containing apolipoprotein B covalently linked to a carbohydrate-rich protein termed apolipoprotein(a) [apo(a)]. Mechanistic and epidemiologic studies indicate that Lp(a) levels are significantly...
Conclusion: This study demonstrated that Lp(a) levels in individuals with acute MI are significantly higher six months after the initial event. Therefore, a single measurement of Lp(a) in the peri-infarction setting is not sufficient to predict the Lp(a)-associated CAD risk in the post-infarction period.
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Conclusions and relevance: In this cohort study of Asian patients with breast cancer, statin use was associated with a reduced risk of cancer-associated death rather than cardiovascular death. Our findings provide evidence to support the use of statins in patients with breast cancer; however, randomized studies are necessary.
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Familial Hypercholesterolemia: Challenges for a High-Risk Population: JACC Focus Seminar 1/3
Source : https://www.sciencedirect.com/science/article/abs/pii/S0735109723045229?via=ihub
The availability of , , and (FH). However, a great number of individuals with FH do not achieve guideline-recommended low-density lipoprotein (LDL) cholesterol levels despite maximal lipid-lowering therapy. Novel therapies...
Conclusions/Relevance: Conduction of cardiovascular outcomes clinical trials in patients with FH can be challenging because of difficulty in recruitment and long periods of follow-up. In the future, the use of validated surrogate measures of atherosclerosis may allow for clinical trials with fewer study participants and shorter duration,...
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LDL cholesterol targets rarely achieved in familial hypercholesterolemia patients: A sex and gender-specific analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37080805/
In routine practice, only a minority of women and men with FH achieved their LDL-C treatment target. Extra efforts have to be made to provide FH patients with reliable information...
Conclusions: In routine practice, only a minority of women and men with FH achieved their LDL-C treatment target. Extra efforts have to be made to provide FH patients with reliable information on the safety of statins and their long-term effects on CVD risk reduction. If statin treatment is insufficient, alternative lipid lowering...
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Sex differences in efficacy and safety of PCSK9 monoclonal antibodies: A real-world registry - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37059655/
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Conclusions: In clinical practice, PCSK9 mAbs are less effective in reducing LDL-c levels in women compared to men and equally safe, implying the importance of sex differences in PCSK9 metabolism.
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