Beneficial Effects of Spirulina Consumption on Brain Health - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35277035/
Spirulina is a microscopic, filamentous cyanobacterium that grows in alkaline water bodies. It is extensively utilized as a nutraceutical food supplement all over the world due to its high levels...
Conclusion/Relevance: This review focuses on the role of Spirulina in the brain, highlighting how it exerts its beneficial anti-inflammatory and antioxidant effects, acting on glial cell activation, and in the prevention and/or progression of neurodegenerative diseases, in particular Parkinson's disease, Alzheimer's disease and Multiple...
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Clinical and genetic features of sitosterolemia in Japan
Source : https://www.sciencedirect.com/science/article/abs/pii/S0009898122000808?via=ihub
We are providing clinical and genetic features of Japanese patients with sitosterolemia. * A particular missense mutation in ABCG5 accounts for 24 % of pathogenic mutation. * There are 3...
Conclusion/Relevance: We are providing a demographic overview of the clinical and genetic backgrounds of Japanese patients with sitosterolemia.
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Comparative efficacy of non-statin lipid-lowering therapies in patients with hypercholesterolemia at increased cardiovascular risk: a network meta-analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35262430/
This study provides insight regarding the comparative efficacy of drugs for which no head-to-head trials exist and suggests that inclisiran, alirocumab, and evolocumab are expected to provide similar clinically meaningful...
Conclusions: This study provides insight regarding the comparative efficacy of drugs for which no head-to-head trials exist and suggests that inclisiran, alirocumab, and evolocumab are expected to provide similar clinically meaningful improvements in low-density lipoprotein cholesterol in patients with hypercholesterolemia on maximally...
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Efficacy and Safety of PCSK9 Monoclonal Antibodies in Patients With Diabetes - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35246337/
doi: 10.1016/j.clinthera.2021.12.005. Online ahead of print. 1 Department of Pharmacology and Toxicology, College of Pharmacy, University of Sulaimani, Sulaimani, Federal Region of Kurdistan, Iraq. 2 Cardiovascular Trials Unit, Manchester University...
Implications: PCSK9monoclonal antibodies markedly reduce LDL-C and consistently reduce cardiovascular mortality in patients with and without diabetes. Current evidence does not suggest an adverse effect of PCSK9 monoclonal antibodies on glycemic parameters.
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Conclusions: PK regulates circulating cholesterol levels through binding to LDLR and inducing its lysosomal degradation. Ablation of PK stabilizes LDLR, decreases LDL cholesterol, and prevents atherosclerotic plaque development. This study suggests that PK is a promising therapeutic target to treat atherosclerotic cardiovascular disease.
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