PCSK9 promotes arterial medial calcification
Source : https://www.atherosclerosis-journal.com/article/S0021-9150(22)00029-6/fulltext
PCSK9 plasma levels are negatively associated with glomerular filtration rate, and atherosclerotic cardiovascular disease further increased PCSK9 plasma levels in a cohort of 594 subjects. * PCSK9 plasma levels are...
Conclusions: Our study reveals a direct role of PCSK9 on vascular calcification induced by higher inorganic phosphate levels associated with renal impairment. This effect appears to be mediated by a switch towards a pro-calcific phenotype of SMCs associated with the release of EVs containing Ca2 and ALP.
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Dr Hamid4yrPCSK9 plasma levels are negatively associated with glomerular filtration rate, and atherosclerotic cardiovascular disease- interesting read
Sex-specific endothelial dysfunction induced by high-cholesterol diet in rats: The role of protein tyrosine kinase and nitric oxide - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35144857/
1 Health Clinical Science Research Center, Zahedan Branch, Islamic Azad University, Zahedan, Iran; Student Research Committee, Islamic Azad University, Zahedan Branch, Zahedan, Iran. 2 Imam Zaman Hospital, Mashad, Iran. 3...
Conclusion: HC diet alters endothelium function through Nitric oxide (NO) and tyrosine kinase pathways in male rats.
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Dr Hamid4yrAtherosclerosis is a chronic process playing a crucial role in the pathogenesis of cardiovascular disease
Relevance: It is hoped that longer follow-ups of people with severe hypercholesterolemia and absence of CAC or plaques will confirm study findings and help improve stratification and guide more aggressive LDL-C level–lowering therapies, even in this so-called high-risk group.
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Effectiveness and safety of PCSK9 inhibitor therapy in patients with familial hypercholesterolemia within a therapeutic program in Poland: Preliminary multicenter data | Chlebus | Cardiology Journal
Source : https://journals.viamedica.pl/cardiology_journal/article/view/86348
Early publication date: 2022-01-11 Krzysztof Chlebus 1 2, Barbara Cybulska 3, Piotr Dobrowolski 4, Marzena Romanowska-Kocejko 5 2, Marta Żarczyńska-Buchowiecka 5 2, Natasza Gilis-Malinowska 1 2, Aneta Stróżyk 2 1,...
Conclusions: This study confirmed high effectiveness of PCSK9 inhibitors in reducing LDL-C levels in patients with FH. Due to restrictive inclusion criteria with LDL-C threshold level > 160 mg/dL (> 4.1 mmol/L) required for participation in the therapeutic program, a relatively small number of FH patients were eligible for treatment.
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Comprehensive chemical profiling of the flowers of Citrus aurantium L. var. amara Engl. and uncovering the active ingredients of lipid lowering
Source : https://www.sciencedirect.com/science/article/abs/pii/S0731708522000425?via=ihub
The structure-DPIs-NL library was developed for characterization of FCAVA. * A total of 228 constituents were characterized in FCAVA. * A simple method for quantification of 19 flavonoids in FCAVA...
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Conclusion: Overall, these findings indicated the potential of FCAVA in the development of functional food or medicine for the prevention and treatment of hyperlipidemia, which could be considered for the improvement of quality standardization of FCAVA.
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