Lipoprotein Particle Profiles Associated with Telomere Length and Telomerase Complex Components - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37299586/
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Conclusions/Relevance: Our results suggest that the lipoprotein profiles are associated with telomere length, TERT, and WRAP53 expression and should be considered when assessing the risk of chronic diseases.
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Analysis of the evolocumab (Repatha®) patient support program for patients with cardiovascular disease in Colombia
Source : https://www.sciencedirect.com/science/article/abs/pii/S021491682300044X?via=ihub
Available online 3 June 2023 Author links open overlay panel, Mariana Pineda-Posada b , , , Show more Las enfermedades cardiovasculares son la principal causa de muerte a nivel mundial.
Conclusion: This is the first real-life study describing patient characteristics, compliance and continuity of treatment for dyslipidemia in a patient support program in Colombia. The overall adherence found was higher than 70%; similar to findings reported in other real-life studies with iPCSK9. However, the reasons for low compliance were...
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A Systematic Review and Meta-Analysis on the Impact of Statin Treatment in HIV Patients on Antiretroviral Therapy - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37174188/
The rate of new human immunodeficiency virus (HIV) infections globally is alarming. Although antiretroviral therapy (ART) improves the quality of life among this group of patients, ARTs are associated with...
Conclusions/Relevance: Finally, compared to placebo, statins significantly reduced total cholesterol (SMD: (-2.87, 95% CI: (-4.08, -1.65), p < 0.0001)). Our results suggest that the statin lipid-lowering effect in PLHIV on ART may elevate immune activation without influencing the viral load and CD4 count. However, due to the limited...
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Feasibility of Short-Term Aggressive Lipid-Lowering Therapy with the PCSK9 Antibody in Acute Coronary Syndrome - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37233171/
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Conclusions: In ACS patients who underwent PCI, short-term PCSK9 antibody therapy with conventional LLT was feasible in this pilot clinical trial. Long-term follow-up in a larger scale clinical trial is warranted.
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Bempedoic Acid: An Emerging Therapy for Uncontrolled Low-Density Lipoprotein (LDL) Cholesterol - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37233162/
Atherosclerotic cardiovascular disease (ASCVD) is a silent epidemic, which is progressing relentlessly across the globe. Developing countries such as India have a high prevalence of dyslipidemia and consequently a huge...
Conclusions: Bempedoic acid is first in class for drugs with unique modes of action of ACL inhibition. In the current era of recent Indian and international guidelines with more stringent LDL-C goal criteria, there is a need for this type of molecule, with the potential of a further ~20% LDL-C reduction post maximally tolerated dose of statin...
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