LDL cholesterol targets rarely achieved in familial hypercholesterolemia patients: A sex and gender-specific analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37080805/
In routine practice, only a minority of women and men with FH achieved their LDL-C treatment target. Extra efforts have to be made to provide FH patients with reliable information...
Conclusions: In routine practice, only a minority of women and men with FH achieved their LDL-C treatment target. Extra efforts have to be made to provide FH patients with reliable information on the safety of statins and their long-term effects on CVD risk reduction. If statin treatment is insufficient, alternative lipid lowering...
Share
Sex differences in efficacy and safety of PCSK9 monoclonal antibodies: A real-world registry - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37059655/
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site. The site is secure....
Conclusions: In clinical practice, PCSK9 mAbs are less effective in reducing LDL-c levels in women compared to men and equally safe, implying the importance of sex differences in PCSK9 metabolism.
Share
PCSK9, a novel immune and ferroptosis related gene in abdominal aortic aneurysm neck - Scientific Reports
Source : https://www.nature.com/articles/s41598-023-33287-9
The gene expression profile of abdominal aortic aneurysm (AAA) neck is not fully understood. The etiology of AAA is considered to be related to atherosclerosis and the inflammatory response, involving...
Conclusion: PCSK9 was highly expressed in AAA neck, and may exert its role through interacting with immune check-points and ferroptosis-related genes.
Share
-
Lipid Management Connect3yrKey Points • Source: Scientific Reports • Conclusion: “PCSK9 was highly expressed in AAA [abdominal aortic aneurysm] neck, and may exert its role through interacting with immune check-points and ferroptosis-related genes …. We found Show More
PCSK9 inhibitor attenuates atherosclerosis by regulating SNHG16/EZH2/TRAF5-mediated VSMC proliferation, migration, and foam cell formation - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37017413/
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site. The site is secure....
Conclusions/Relevance: The protective regulation of PCSK9 inhibitor was observed both in high-fat diet (HFD)-fed mice and oxidized low-density lipoprotein (ox-LDL)-treated VSMC, as manifested in the decreased the atherosclerotic lesions in vivo, as well as the weakened cell proliferation, migration, and formation of foam cells in vitro....
Share
The cholesterol-lowering effect of statins is modified by LILRB5 intolerance genotype: Results from a recruit-by-genotype clinical trial
Source : https://www.frontiersin.org/articles/10.3389/fphar.2023.1090010/full
Background/Aims: Statin intolerance leads to poor adherence to statin therapy, resulting in a failure to achieve desired cholesterol reduction and adverse outcomes. The LILRB5 Asp247Gly genotype has been identified as...
Conclusion: The Asp247Gly variant in LILRB5, previously associated with statin intolerance, was associated with differential increases in creatine kinase and total cholesterol and non-HDL cholesterol-lowering response to atorvastatin. Taken together, these results suggest that this variant could have utility in precision cardiovascular...
Share