PCSK9 promotes arterial medial calcification
Source : https://www.atherosclerosis-journal.com/article/S0021-9150(22)00029-6/fulltext
PCSK9 plasma levels are negatively associated with glomerular filtration rate, and atherosclerotic cardiovascular disease further increased PCSK9 plasma levels in a cohort of 594 subjects. * PCSK9 plasma levels are...
Conclusions: Our study reveals a direct role of PCSK9 on vascular calcification induced by higher inorganic phosphate levels associated with renal impairment. This effect appears to be mediated by a switch towards a pro-calcific phenotype of SMCs associated with the release of EVs containing Ca2 and ALP.
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Dr Hamid4yrPCSK9 plasma levels are negatively associated with glomerular filtration rate, and atherosclerotic cardiovascular disease- interesting read
Effectiveness and safety of PCSK9 inhibitor therapy in patients with familial hypercholesterolemia within a therapeutic program in Poland: Preliminary multicenter data | Chlebus | Cardiology Journal
Source : https://journals.viamedica.pl/cardiology_journal/article/view/86348
Early publication date: 2022-01-11 Krzysztof Chlebus 1 2, Barbara Cybulska 3, Piotr Dobrowolski 4, Marzena Romanowska-Kocejko 5 2, Marta Żarczyńska-Buchowiecka 5 2, Natasza Gilis-Malinowska 1 2, Aneta Stróżyk 2 1,...
Conclusions: This study confirmed high effectiveness of PCSK9 inhibitors in reducing LDL-C levels in patients with FH. Due to restrictive inclusion criteria with LDL-C threshold level > 160 mg/dL (> 4.1 mmol/L) required for participation in the therapeutic program, a relatively small number of FH patients were eligible for treatment.
Effects of preconception lifestyle intervention in infertile women with obesity: The FIT-PLESE randomized controlled trial
Source : https://journals.plos.org/plosmedicine/article?id=10.1371/journal.pmed.1003883
Richard S. Legro, Karl R. Hansen, Michael P. Diamond, Anne Z. Steiner, Christos Coutifaris, Marcelle I. Cedars, Kathleen M. Hoeger, Rebecca Usadi, Erica B. Johnstone, Daniel J. Haisenleder Subject Areas...
Conclusions: A preconception intensive lifestyle intervention for weight loss did not improve fertility or birth outcomes compared to an exercise intervention without targeted weight loss. Improvement in metabolic health may not translate into improved female fecundity.
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Dr Hamid4yrImprovement in metabolic health Should be discussed with women
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Michelle Jardine4yrI see so many obese women with problems with fertility and often with weight loss and control of their obesity taking conceive
Comprehensive chemical profiling of the flowers of Citrus aurantium L. var. amara Engl. and uncovering the active ingredients of lipid lowering
Source : https://www.sciencedirect.com/science/article/abs/pii/S0731708522000425?via=ihub
The structure-DPIs-NL library was developed for characterization of FCAVA. * A total of 228 constituents were characterized in FCAVA. * A simple method for quantification of 19 flavonoids in FCAVA...
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Conclusion: Overall, these findings indicated the potential of FCAVA in the development of functional food or medicine for the prevention and treatment of hyperlipidemia, which could be considered for the improvement of quality standardization of FCAVA.
Long-term effects of evolocumab in participants with HIV and dyslipidemia: results from the open-label extension period - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35025817/
doi: 10.1097/QAD.0000000000003175. Online ahead of print. 1 Sorbonne Université, GRC no.
Conclusion: Long-term administration of evolocumab lowered LDL-C and non-HDL-C, allowing more PWH to achieve recommended lipid goals with no serious adverse events.
Sex differences in low-density lipoprotein cholesterol reduction with PCSK9 inhibitors in real world patients: the LIPID-REAL Registry - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34983910/
doi: 10.1097/FJC.0000000000001205. Online ahead of print. 1 Cardiology Department. Hospital Universitario de San Juan. Alicante, Spain Unidad de Investigación en Cardiología. Fundación para el Fomento de la Investigación Sanitaria y...
Conclusion: This multicentre and retrospective registry of real-world patients treated with PCSK9 inhibitors highlights significant gender differences in LDLc reduction.
Molecular genetics for familial hypercholesterolemia
Source : https://imrpress.com/journal/RCM/23/1/10.31083/j.rcm2301004
IMR Press is a leading publisher of open access peer-reviewed biomedical and life sciences journals. We aim to facilitate the dissemination of high-quality research in the area of biomedical science....
Conclusion/Relevance: "These results permit the following conclusions: (a) when participants were solely ascertained for abnormal LDL cholesterol level (>190 mg/dL), we identified an FH mutation in 25.05% of hypercholesterolemic patients. These sequencing yelds are partially overlapping with other previous screening studies [7, 8]; (b) CAD...
Laparoscopic diagnosis of idiopathic left ovarian vein thrombosis in a 27-year-old woman - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35096407/
Idiopathic left ovarian vein thrombosis was diagnosed in a 27-year-old woman at the time of a diagnostic laparoscopy performed because of a suspected ovarian torsion. The diagnosis was confirmed by...
Relevance: During follow-up it became clear that the patient was already diagnosed with familial hypercholesterolemia before the occurrence of the ovarian vein thrombosis. It remains unclear if familial hypercholesterolemia played a role in the occurrence of ovarian vein thrombosis in our patient.
THE EFFECT OF EVOLOCUMAB ALONE AND IN COMBINATION WITH ATORVASTATIN ON LIPID PROFILE - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35058387/
Conclusions: Preproteins convert as esubtilisin/kexin type 9 inhibitor regulates the serum levels of lipid and cholesterol by lowering LDL-C, and the results also indicate that combination of evolocumab and atorvastatin...
Conclusion: Preproteins convert as esubtilisin/kexin type 9 inhibitor regulates the serum levels of lipid and cholesterol by lowering LDL-C, and the results also indicate that combination of evolocumab and atorvastatin are more potent in lowering the lipid profile and then reduce progression of atherosclerosis than evolocumab alone in rabbits...
The Impact of the COVID-19 Outbreak on Patients’ Adherence to PCSK9 Inhibitors Therapy
Source : https://www.mdpi.com/2077-0383/11/3/475/htm
PCSK9 inhibitors (PCSK9i) are monoclonal antibodies that have been shown to be effective in reducing both LDL cholesterol (LDL-C) values and major cardiovascular events in patients at high cardiovascular risk....
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Dr Hamid4yrFacilitating patients’ access to PCSK9i and enhancing telemedicine seem to be effective strategies to ensure the continuity of care and appropriate management of these patients.
Daily intake of up to two eggs for 11 weeks does not affect the cholesterol balance of Chinese young adults
Source : https://onlinelibrary.wiley.com/doi/full/10.1002/fsn3.2734
Dexin Zhang , Deyuan Li , Fang Yang , Corresponding Author Fang Yang School of Laboratory Medicine, Hubei University of Chinese Medicine, Wuhan, China Correspondence Deyuan Li, Functional Food Research,...
These results demonstrate that intake of up to two eggs a day had little effect on biomarkers of CVDs in young, healthy Chinese college students and provided useful evidence for the dietary guidelines regarding egg consumption.
Circulating GPIHBP1 levels and microvascular complications in patients with type 2 diabetes: A cross-sectional study
Source : https://www.lipidjournal.com/article/S1933-2874(22)00021-6/pdf
Dyslipidemia is a major risk factor for coronary heart disease (CHD) in patients with type 2 diabetes mellitus (T2DM),1,2 whose risk of CHD is two-to three-fold higher than in individuals...
Highlights: "Serum GPIHBP1 levels were higher in patients with type 2 diabetes mellitus (T2DM). Serum GPIHBP1 levels were higher in T2DM patients with microvascular complications. Serum GPIHBP1 levels independently associated with T2DM microvascular complications".
Highlights: "L. plantarum ECGC 13110402 supports the reduction of multiple cholesterol biomarkers. L. plantarum ECGC 13110402 has high bile salt hydrolase activity. L. plantarum ECGC 13110402 is a well-tolerated and safe probiotic strain. L. plantarum ECGC 13110402 improves the lipid profiles of dyslipidaemic patients".
In conclusion, coronary CTA has provided welcome insights into the role of Lp(a) in plaque progression. In concert with imaging evidence, the clinical evidence on whether substantially lowering Lp(a) will reduce cardiovascular events is expected in 2025 from Lp(a) HORIZON. A positive trial is likely to lead to additional trials and new drugs...
Personalizing cholesterol treatment recommendations for primary cardiovascular disease prevention - Scientific Reports
Source : https://www.nature.com/articles/s41598-021-03796-6
Statin therapy is the cornerstone of preventing atherosclerotic cardiovascular disease (ASCVD), primarily by reducing low density lipoprotein cholesterol (LDL-C) levels. Optimal statin therapy decisions rely on shared decision making and...
Recommendations included low- or moderate-intensity statins for maximum LDL-C lowering in nearly half the test set, which is discordant with their expected guideline-based efficacy. A data-driven personalized statin recommendation approach may inform shared decision making in areas of uncertainty, and highlight unexpected efficacy-effectiveness...
FDA Clears Novartis Inclisiran to Lower Cholesterol With Only Two Doses a Year
January 4, 2022 - The U.S. Food and Drug Administration (FDA) has cleared Novartis' inclisiran (Leqvio), the first small interfering RNA (siRNA) therapy to lower low-density lipoprotein cholesterol (LDL-C) with...
“Leqvio is a revolutionary approach to lower LDL-C, and creates new possibilities for how healthcare systems can impact cardiovascular disease, a defining public health challenge of our time,” said Vas Narasimhan, Novartis CEO. “We now have the opportunity, working together with partners, to provide this first-ever approved...
Triglyceride/low-density-lipoprotein cholesterol ratio is the most valuable predictor for increased small, dense LDL in type 2 diabetes patients - Lipids in Health and Disease
Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-021-01612-8
Background Small, dense low-density lipoprotein (sd-LDL) increases in type 2 diabetes patients and causes arteriosclerosis. Non-high-density-lipoprotein cholesterol (non-HDL-C) is thought to be useful for predicting arteriosclerosis and sd-LDL elevation; however,...
Conclusion: "The TG/LDL-C ratio is a reliable surrogate lipid marker of sd-LDL and superior to non–HDL-C in type 2 diabetes patients not treated with statins."
Conclusion: "This study demonstrated that both low and high levels of LDL-C were associated with a higher risk of diabetes diagnosis. Patients with either high or low LDL-C may need to be closely monitored for the risk of diabetes."
Bempedoic acid in patients with type 2 diabetes mellitus, prediabetes, and normoglycaemia: a post hoc analysis of efficacy and glycaemic control using pooled data from phase 3 clinical trials - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34981622/
doi: 10.1111/dom.14645. Online ahead of print. 1 Li Ka Shing Knowledge Institute, St. Michael's Hospital, University of Toronto, Toronto, Ontario, Canada. 2 Medical University of Łódź, Łódź, Poland. 3 University...
Conclusion: Bempedoic acid significantly lowered LDL-C across glycaemic strata and did not worsen glycaemic parameters nor increase incidence of new-onset diabetes vs placebo over a median follow-up of 1 year. This article is protected by copyright. All rights reserved.
Relationship between adiponectin and intramuscular fat content determined by ultrasonography in older adults
Source : https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0262271
Age-associated intramuscular adipose tissue (IntraMAT) deposition induces the development of insulin resistance and metabolic syndrome. However, the relationship between IntraMAT and biochemical parameters in older adults remains unclear. The purpose...
"These data suggest that adiponectin level is related to IntraMAT content, independent of VAT in normal-weight older adults. The dynamics of adiponectin might not be similar to those of other circulating biochemical parameters in older men and women. "