Effect of a PCSK9 Inhibitor and a Statin on Cholesterol Efflux Capacity: a Limitation of Current Cholesterol-Lowering Treatments? - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35294778/
In normolipidaemic men, evolocumab and atorvastatin decrease the capacity of whole plasma to efflux cellular cholesterol. These effects may be chiefly owing to a fall in the availability of apoB-100...
Conclusions: In normolipidaemic men, evolocumab and atorvastatin decrease the capacity of whole plasma to efflux cellular cholesterol. These effects may be chiefly owing to a fall in the availability of apoB-100 containing lipoproteins. Reduction in circulating lipoprotein(a) may also contribute to the decrease in whole plasma cholesterol...
The Role of Endothelial Progenitor Cells in Atherosclerosis and Impact of Anti-Lipemic Treatments on Endothelial Repair - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35269807/
Cardiovascular complications are associated with advanced atherosclerosis. Although atherosclerosis is still regarded as an incurable disease, at least in its more advanced stages, the discovery of endothelial progenitor cells (EPCs),...
Conclusions: Many currently available drugs that impact cardiovascular morbidity and mortality have shown a positive effect on EPC biology. This review examines the role of endothelial progenitor cells in atherosclerosis development, and the impact standard antilipemic drugs, including statins, fibrates, and ezetimibe, as well as more novel...
Clinical characterization of familial hypercholesterolemia due to an amish founder mutation in Apolipoprotein B - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35300601/
We provide a detailed description of the serum lipids, atherosclerotic plaque burden, vascular stiffness, and endothelial function among children and young adults with FH due to heterozygous ApoB R3500Q ....
Conclusions: We provide a detailed description of the serum lipids, atherosclerotic plaque burden, vascular stiffness, and endothelial function among children and young adults with FH due to heterozygous ApoBR3500Q. Fasting LDL-C was lower than what is seen with other forms of FH, and even normal in several ApoBR3500Q heterozygotes,...
Drug Treatment of Hypercholesterolemia in Older Adults: Focus on Newer Agents - Drugs & Aging
Source : https://link.springer.com/article/10.1007/s40266-022-00928-z
There is increasing research interest in cholesterol-lowering therapy in older patients. The newer lipid-lowering agents (the proprotein convertase subtilisin/kexin type 9 [PCSK9] inhibitors evolocumab and alirocumab; the PCSK9 synthesis inhibitor...
Conclusions: The newer lipid-lowering agents could be added to other lipid-lowering medication or used as an alternative treatment in older patients with documented statin intolerance (as is already recommended in guidelines for the PCSK9 inhibitors), such as myopathy. Especially in older patients needing high-intensity therapy despite...
Colonic Microbiota Profile Characterization of the Responsiveness to Dietary Fibre Treatment in Hypercholesterolemia - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35276884/
This study aimed to determine how the microbiota profile might be predisposed to a better response in blood lipid profiles due to dietary fibre supplementation. A three-arm intervention study that...
Conclusion: It was concluded that the non-responsiveness to dietary fibre treatment might be mediated by the lack of ability to maintain a stable SCFA producing bacteria diversity and composition after extra fibre intake.
Beneficial Effects of Spirulina Consumption on Brain Health - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35277035/
Spirulina is a microscopic, filamentous cyanobacterium that grows in alkaline water bodies. It is extensively utilized as a nutraceutical food supplement all over the world due to its high levels...
Conclusion/Relevance: This review focuses on the role of Spirulina in the brain, highlighting how it exerts its beneficial anti-inflammatory and antioxidant effects, acting on glial cell activation, and in the prevention and/or progression of neurodegenerative diseases, in particular Parkinson's disease, Alzheimer's disease and Multiple...
Clinical and genetic features of sitosterolemia in Japan
Source : https://www.sciencedirect.com/science/article/abs/pii/S0009898122000808?via=ihub
We are providing clinical and genetic features of Japanese patients with sitosterolemia. * A particular missense mutation in ABCG5 accounts for 24 % of pathogenic mutation. * There are 3...
Conclusion/Relevance: We are providing a demographic overview of the clinical and genetic backgrounds of Japanese patients with sitosterolemia.
Comparative efficacy of non-statin lipid-lowering therapies in patients with hypercholesterolemia at increased cardiovascular risk: a network meta-analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35262430/
This study provides insight regarding the comparative efficacy of drugs for which no head-to-head trials exist and suggests that inclisiran, alirocumab, and evolocumab are expected to provide similar clinically meaningful...
Conclusions: This study provides insight regarding the comparative efficacy of drugs for which no head-to-head trials exist and suggests that inclisiran, alirocumab, and evolocumab are expected to provide similar clinically meaningful improvements in low-density lipoprotein cholesterol in patients with hypercholesterolemia on maximally...
Efficacy and Safety of PCSK9 Monoclonal Antibodies in Patients With Diabetes - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35246337/
doi: 10.1016/j.clinthera.2021.12.005. Online ahead of print. 1 Department of Pharmacology and Toxicology, College of Pharmacy, University of Sulaimani, Sulaimani, Federal Region of Kurdistan, Iraq. 2 Cardiovascular Trials Unit, Manchester University...
Implications: PCSK9monoclonal antibodies markedly reduce LDL-C and consistently reduce cardiovascular mortality in patients with and without diabetes. Current evidence does not suggest an adverse effect of PCSK9 monoclonal antibodies on glycemic parameters.
Conclusions: PK regulates circulating cholesterol levels through binding to LDLR and inducing its lysosomal degradation. Ablation of PK stabilizes LDLR, decreases LDL cholesterol, and prevents atherosclerotic plaque development. This study suggests that PK is a promising therapeutic target to treat atherosclerotic cardiovascular disease.
Effect of Evolocumab in Patients With Prior Percutaneous Coronary Intervention - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35209731/
2022 Feb 25;CIRCINTERVENTIONS121011382. doi: 10.1161/CIRCINTERVENTIONS.121.011382. Online ahead of print. 1 Academic Research Organization, Hospital Israelita Albert Einstein, Sao Paulo, Brazil (R.H.M.F.). 2 Instituto do Coracao (InCor), Hospital das Clinicas da...
Conclusions: Evolocumab reduces the risk of MACE in patients with prior PCI including the risk of coronary revascularization, with directionally consistent effects across several types of revascularization procedures, including coronary artery bypass grafting and PCI for stent or graft failure.
Trends in PCSK9 Inhibitor Utilization in the United States, Europe and Other Countries: An Analysis of International Sales Data - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35240102/
First approved in July 2015, proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors are costly lipid-lowering drugs. Their utilization has important policy and clinical implications but has not been assessed...
Relevance: First approved in July 2015, proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors are costly lipid-lowering drugs. Their utilization has important policy and clinical implications but has not been assessed across different geographical regions. The objective of this study was to describe trends in PCSK9 inhibitor adoption...
Synergistic Effects of Inflammation and Atherogenic Dyslipidemia on Subclinical Carotid Atherosclerosis Assessed by Ultrasound in Patients with Familial Hypercholesterolemia and Their Family Members - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35203576/
doi: 10.3390/biomedicines10020367. 1 Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital, Taipei 100225, Taiwan. 2 Department of Environmental and Occupational Medicine, National Taiwan University Hospital, Taipei 100225,...
Conclusion: Our results demonstrated that systemic inflammation, in terms of higher hsCRP levels ≥ 2 mg/L, synergistically contributed to atherogenic dyslipidemia of higher LDL-C or a higher TC/HDL-C ratio on subclinical atherosclerosis.
Approaches to Visualising Endocytosis of LDL-Related Lipoproteins - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35204658/
Endocytosis is the process by which molecules are actively transported into cells. It can take on a variety of forms depending on the cellular machinery involved ranging from specific receptor-mediated...
Conclusion/Relevance: The aim of this review is to outline the many endocytic pathways utilised for lipoprotein uptake. It explores the various experimental approaches that have been applied to visualise lipoprotein endocytosis with an emphasis on LDL and its more complex counterpart, lipoprotein(a) [Lp(a)]. Finally, we look at new...
Managing Atherosclerotic Cardiovascular Risk in Young Adults: JACC State-of-the-Art Review
Source : https://www.sciencedirect.com/science/article/abs/pii/S0735109721084448?via=ihub
Addressing risk factors in individuals aged 20-39 years can reduce premature atherosclerotic cardiovascular disease. * Tobacco cessation and managing hypertension, hypercholesterolemia, diabetes, sex-specific risk factors, and metabolic syndrome are essential....
Relevance: The authors update current thinking on lipid risk factors such as triglycerides, non–high-density lipoprotein cholesterol, apolipoprotein B, or lipoprotein (a) that are useful in understanding an individual’s long-term ASCVD risk. The authors review emerging strategies, such as coronary artery calcium and polygenic risk scores...
Pharmacological treatment with lipid-lowering agents after molecular identification of familial hypercholesterolemia: results from the Hipercol Brasil cohort - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35181259/
Index cases with a positive genetic result increase their prevalence of lipid-lowering medication use. Positive relatives did not have the expected adherence; we could notice a significant increase in the...
Conclusion: Index cases with a positive genetic result increase their prevalence of lipid-lowering medication use. Positive relatives did not have the expected adherence; we could notice a significant increase in the prevalence of treatment starting after a positive genetic test. The independent predictors for lipid-lowering treatment were...
Clinical decision support for familial hypercholesterolemia (CDS-FH): Rationale and design of a cluster randomized trial in primary care
Source : https://www.sciencedirect.com/science/article/pii/S000287032200031X?via=ihub
Familial hypercholesterolemia (FH) is an underdiagnosed and undertreated genetic disorder with high risk of premature atherosclerotic cardiovascular disease and death. Clinical decision support (CDS) systems have the potential to aid...
Conclusion: Despite increasing awareness of FH, the condition remains underdiagnosed and undertreated. The present study will investigate whether a CDS can increase the number of patients being diagnosed with FH.
Low density lipoprotein cholesterol levels exceed the recommended European threshold for PCSK9i initiation: lessons from the HEYMANS study - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35175350/
Across Europe, LDL-C levels at evolocumab initiation were three times higher than recommended thresholds for PCSK9i initiation, reflecting disparities between implementation and guidelines. More patients attained risk-based LDL-C goals when...
Conclusions: Across Europe, LDL-C levels at evolocumab initiation were three times higher than recommended thresholds for PCSK9i initiation, reflecting disparities between implementation and guidelines. More patients attained risk-based LDL-C goals when receiving evolocumab in combination with LLT versus those not receiving combination...
Sex-specific endothelial dysfunction induced by high-cholesterol diet in rats: The role of protein tyrosine kinase and nitric oxide - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35144857/
1 Health Clinical Science Research Center, Zahedan Branch, Islamic Azad University, Zahedan, Iran; Student Research Committee, Islamic Azad University, Zahedan Branch, Zahedan, Iran. 2 Imam Zaman Hospital, Mashad, Iran. 3...
Conclusion: HC diet alters endothelium function through Nitric oxide (NO) and tyrosine kinase pathways in male rats.
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Dr Hamid4yrAtherosclerosis is a chronic process playing a crucial role in the pathogenesis of cardiovascular disease
Relevance: It is hoped that longer follow-ups of people with severe hypercholesterolemia and absence of CAC or plaques will confirm study findings and help improve stratification and guide more aggressive LDL-C level–lowering therapies, even in this so-called high-risk group.