Is Deprescription of Ezetimibe Safe in Familial Hypercholesterolemia Patients Taking Evolocumab?
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9039577/
Language: English | French Shyann Hang, BSc, a Julieta Lazarte, PhD, a, b, c and Robert A. Hegele, MD a, b, c, ∗ We evaluated whether low-density lipoprotein cholesterol (LDL-C)...
Relevance: We evaluated whether low-density lipoprotein cholesterol (LDL-C) levels in familial hypercholesterolemia patients on triple lipid-lowering therapy would remain below intensification threshold values after withdrawal of ezetimibe.
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Comparison of Evolocumab and Ezetimibe, Both Combined with Statin Therapy, for Patients with Recent Acute Coronary Syndrome: A Cost-Effectiveness Analysis from the Chinese Healthcare Perspective - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35467312/
doi: 10.1007/s10557-021-07276-x. Online ahead of print. 1 The Research Center of National Drug Policy & Ecosystem, China Pharmaceutical University, Nanjing, China. 2 School of Pharmacy, Hangzhou Medical College, Hangzhou, China....
Conclusion: Compared with ezetimibe statins, the combination of evolocumab statins was found to be cost-effective at a threshold of 217,341 yuan (three times per capita GDP, 2020) in patients with recent ACS events in China.
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Approach to patients with elevated low-density lipoprotein cholesterol levels - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35487874/
Elevated low-density lipoprotein cholesterol (LDL-C) levels increase the risk of atherosclerotic cardiovascular disease (ASCVD) and lowering LDL-C levels reduces the risk of ASCVD. In patients with elevated LDL-C levels it...
Conclusion: Specifically, we discuss evidence indicating that the sooner one initiates therapy the better and the greater the reduction in LDL-C the better. Additionally, the higher the LDL-C level and the higher the risk of ASCVD, the greater the benefits of treatment. Using these principles will help in making decisions regarding the...
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The National Cardiovascular Data Registry Data Quality Program 2020: JACC State-of-the-Art Review - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35483759/
The National Cardiovascular Data Registry is a group of registries maintained by the American College of Cardiology Foundation. These registries are used by a diverse constituency to improve the quality...
Relevance: The National Cardiovascular Data Registry is a group of registries maintained by the American College of Cardiology Foundation. These registries are used by a diverse constituency to improve the quality and outcomes of cardiovascular care, to assess the safety and effectiveness of new therapies, and for research.
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Atherosclerotic cardiovascular disease burden in patients with familial hypercholesterolemia: interpretation of data on involvement of different vascular beds - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35485652/
Familial hypercholesterolemia (FH) is a monogenic, autosomal dominant disorder that results in a rise of low‑density lipoprotein cholesterol (LDL‑C) and markedly increased risk of premature atherosclerotic cardiovascular disease. FH is...
Conclusion: Providing a systematic characteristic of patients with FH with respect to the presence and extent of atherosclerotic lesions in different vascular beds may have implications for daily practice not only for patients with FH but also for a larger number of patients with very high plasma LDL‑C concentrations.
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