Hyperlipidemia patients carrying LDLR splicing mutation c.1187-2A>G respond favorably to rosuvastatin and PCSK9 inhibitor evolocumab - Molecular Genetics and Genomics
Source : https://link.springer.com/article/10.1007/s00438-022-01892-4
Mutations in the LDL receptor gene LDLR cause familial hypercholesterolemia (FH); however, the pharmacogenomics of specific LDLR mutations remains poorly understood. The goals of this study were to identify the...
Conclusion/Relevance: These results suggest that combined treatment with rosuvastatin (but not lovastatin or ezetimibe) and evolocumab can control LDL-C to meet the LDL-C treatment goal for patients with LDLR splicing mutation c.1187-2A>G.
Share
Efficacy and Safety of Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors as Adjuvant Treatments for Patients with Hypercholesterolemia Treated with Statin: A Systematic Review and Network Meta-analysis
Source : https://www.frontiersin.org/articles/10.3389/fphar.2022.832614/full
Background: The proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors are potent LDL-C lowering agents. However, few head-to-head studies evaluated the efficacy on the lowering in other atherogenic apolipoproteins and safety...
Conclusion: PCSK9 inhibitors showed a significant effect on the reduction in LDL-C, ApoB, and Lp(a) levels in statin-treated patients. Evolocumab 140 mg Q2W showed significantly larger degrees of LDL-C, ApoB, and Lp(a) reduction.
Share
Acute Effect of Evolocumab on Lipoprotein(a) Level and Inflammation in Patients with Coronary Artery Disease - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35448076/
doi: 10.3390/jcdd9040101. 1 Division of Cardiology, Department of Internal Medicine, Kyung Hee University Hospital, Kyung Hee University, Seoul 02447, Korea. 2 Department of Medicine, Graduate School of Medicine, Kyung Hee...
Conclusions: One-time PCSK9 inhibitor treatment may be effective in lowering Lp(a) levels in Korean patients in the short term.
Share
PCSK9 inhibition protects against myocardial ischemia-reperfusion injury via suppressing autophagy
Source : https://www.sciencedirect.com/science/article/abs/pii/S0026286222000619?via=ihub
the expression levels of PCSK9 and autophagy markers rose in a proportional ratio with increasing reperfusion time, peaking at 1 day of reperfusion and thereafter decreased. Meanwhile, we believe that...
Conclusion/Relevance: These results suggest that combined treatment with rosuvastatin (but not lovastatin or ezetimibe) and evolocumab can control LDL-C to meet the LDL-C treatment goal for patients with LDLR splicing mutation c.1187-2A>G.
Share
Does eating eggs matter? - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35420270/
Dietary cholesterol is absorbed in proportion to the amount ingested, blocking its hepatic synthesis, increasing its biliary excretion, only slightly increasing production of bile acids while potentially raising the serum...
Conclusion/Relevance: A practical useful suggestion is to measure for a few weeks the total serum cholesterol and its fractions at least three times before and during the intake of eggs that the candidate wishes to maintain in his usual dietary practice as an efficient procedure to identify those who respond with undesirable increases in serum...
Share
