Conclusion: "Tamoxifen can alter the lipid profile in females, particularly by decreasing TC, LDL-C and HDLsingle bondC. Tamoxifen can further reduce TC and LDL-C if the dose of administration is ≥20 mg/day, the treatment duration is ≤52 weeks and if it prescribed in subjects with dyslipidemia."
Share
Among all subjects, the obesity defined by BMI is cross-correlated with an increase in WC. However, in extremely obese women in the United States, there is a lack of a direct relationship between BMI and WC. There was also a clear correlation between the relative change in WC and serum lipid levels in subjects of different ethnic groups. This...
Share
FDA approves Novartis Leqvio® (inclisiran), first-in-class siRNA to lower cholesterol and keep it low with two doses a year
Source : https://www.trivano.com/aandeel/fda-approves-novartis-leqvioar.2049-330141.persbericht
Ad hoc announcement pursuant to Art. 53 LR With two maintenance doses a year, Leqvio is the first and only FDA-approved small interfering RNA (siRNA) therapy for LDL-C (bad cholesterol)...
“Leqvio is a revolutionary approach to lower LDL-C, and creates new possibilities for how healthcare systems can impact cardiovascular disease, a defining public health challenge of our time,” said Vas Narasimhan, Novartis CEO. “We now have the opportunity, working together with partners, to provide this first-ever approved...
Share
[Influence of ApoE gene polymorphisms on therapeutic effects of lipid-lowering statins among patients with ischemic cerebral infarction].
Source : https://europepmc.org/article/med/34964977
Objective To assess the influence of apolipoprotein E (ApoE) gene polymorphisms on the therapeutic effect of lipid-lowering statins in patients with ischemic cerebral infarction. Methods One hundred and six patients...
Conclusion: "ApoE gene polymorphisms are closely correlated with the therapeutic effect of lipid-lowering statins in patients with ischemic cerebral infarction. The lipid-lowering effects are more significant in patients with E2 and E3 genotypes, but were poor in those with the E4 genotype. Personalized regimens should be applied."
Share
Patients with Dipper and Nondipper High-Normal Blood Pressure Were Associated with Left Ventricular Mass
Source : https://doi.org/10.1155/2021/6946418
Purpose . High-normal blood pressure has been suggested to associate with target organ damage and higher left ventricular mass index (LVMI). Our aim is to find the association between people...
Conclusion: After multiple relevant clinical confounding factors were adjusted, patients with dipper and nondipper high-normal blood pressure had higher LVMI. Abnormalities in circadian blood pressure variability may be associated with the left ventricular hypertrophy.
Share