Inclisiran, Low-Density Lipoprotein Cholesterol and Lipoprotein (a) - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/37111334/
Dyslipidemia treatment is of major importance in reducing the risk of atherosclerotic cardiovascular disease (ASCVD), which is still the most common cause of death worldwide. During the last decade, a...
Conclusions: Inclisiran exerts a prolonged and significant LDL-C-lowering effect based on its unique mechanism of action. Some of the ORION trials have been completed confirming that inclisiran effectively reduced LDL-C in patients with elevated LDL-C, despite maximally tolerated statin therapy (±ezetimibe), in different clinical...
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Conclusions: HCRU within the first year of ASCVD diagnosis is substantial among patients with ASCVD and elevated Lp(a). Relatively higher rates of inpatient hospitalizations, increased LOS per hospitalization, and requirement of revascularization procedures within the first year of ASCVD index diagnosis were observed in patients with...
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Historical Review of the Use of Relative Risk Statistics in the Portrayal of the Purported Hazards of High LDL Cholesterol and the Benefits of Lipid-Lowering Therapy
The manner in which clinical trial investigators present their findings to healthcare providers and the public can have a substantial influence on their impact. For example, if a heart attack...
Conclusions/Relevance: We assert that the emphasis on RR coupled with insufficient disclosure of AR in the reporting of RCT outcomes has led healthcare providers and the public to overestimate concerns about high cholesterol and to be misled as to the magnitude of the benefits of cholesterol-lowering therapy. The goal of this review is to...
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Rare primary dyslipidaemias associated with low LDL and HDL cholesterol values in Portugal
Source : https://www.frontiersin.org/articles/10.3389/fgene.2022.1088040/full
Background: Dyslipidaemia represents a group of disorders of lipid metabolism, characterized by either an increase or decrease in lipid particles, usually associated with triglycerides, LDL cholesterol (LDL-C) and/or HDL cholesterol...
Conclusion: We report here the clinical and molecular characteristics of seven patients with rare lipid disorders associated with low LDL or low HDL. Two cases presented with hypoalphalipoproteinemia, and the genetic workup allowed the diagnosis of Tangier disease in one and of Fish Eye Disease in the other. These are ultrarare disorders,...
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Natural language processing to identify reasons for sex disparity in statin prescriptions
Source : https://www.sciencedirect.com/science/article/pii/S2666667723000375?via=ihub
Statins are the cornerstone of treatment of patients with atherosclerotic cardiovascular disease (ASCVD). Despite this, multiple studies have shown that women with ASCVD are less likely to be prescribed statins...
Conclusions: Women with ASCVD were less likely to be prescribed guideline-directed statins compared with men. NLP identified additional sex-based statin disparities and reasons for statin non-prescription in clinical notes of patients with ASCVD.
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