Statin therapy for primary prevention in men: What is the role for coronary artery calcium?
Source : https://www.lipidjournal.com/article/S1933-2874(22)00299-9/fulltext
Statin therapy is widely prescribed for patients with established ASCVD (secondary prevention). Meta-analysis of randomized clinical trials (RCTs) show conclusively that statins substantially reduce recurrent major ASCVD events (myocardial infarction...
Highlights: Statins reduce atherosclerotic cardiovascular disease in men and women. Men develop coronary atherosclerosis more rapidly than women. Most men 55 to 75 years are statin eligible by Pooled Cohort Equations. But statin eligibility may be better guided by coronary artery calcium (CAC).
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Gene and cell therapy approaches for familial hypercholesterolemia: An update
Source : https://www.sciencedirect.com/science/article/abs/pii/S1359644622004639?via=ihub
Available online 23 December 2022, 103470 Author links open overlay panel Amirhossein Sahebkar Person 5 Envelope Show more * Familial hypercholesterolemia (FH) is a common inherited autosomal codominant disorder. *...
Relevance: We reviewed numerous studies that used the innovative clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 gene editing technique to correct FH-causing genetic abnormalities.
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Lipid-Lowering Trials Are Not Representative of Patients Managed in Clinical Practice: A Systematic Review and Meta-Analysis of Exclusion Criteria - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36565207/
Background Randomized clinical trials (RCTs) might not be representative of the real-world population because of unreasonable exclusion criteria. We sought to determine which groups of patients are excluded from RCTs...
Conclusions: The majority of lipid‐lowering therapy trials excluded patients with common diseases, such as moderate‐to‐severe kidney disease or heart failure or with immunosuppression. Underrepresenting certain populations, including women and older adults, might lead to limited transportability of study results and uncertainty on...
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The effects of three weight management methods on body composition and serum lipids of overweight and obese people
Source : https://www.frontiersin.org/articles/10.3389/fnut.2022.1073576/full
IntroductionObesity has become a major health problem worldwide. Diet management is an important means of weight loss.
Conclusions: Our findings showed that the 5 2 IF may be more effective in reducing total weight and body fat, and HPD may be more helpful in preventing lean body mass loss during a short-term weight loss intervention.
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PCSK9: A emerging participant in heart failure
Source : https://www.sciencedirect.com/science/article/pii/S0753332222014950?via=ihub
HF needs new treatment strategies to ameliorate its present situation. * HF's pathogenesis involved cell death, energy metabolism, inflammation etc. * PCSK9 contributes to the pathogenesis of HF and may...
Conclusions: The purpose of this review is to summarize the potential mechanism of PCSK9’s involvement in heart failure, thereby providing a new treatment strategy for heart failure.
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