Genetic Spectrum of Familial Hypercholesterolaemia in the Malaysian Community: Identification of Pathogenic Gene Variants Using Targeted Next-Generation Sequencing - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36499307/
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Conclusions/Relevance: The detection rate of genetic confirmation is similar between potential and possible FH groups, suggesting a need for genetic confirmation in index cases from both groups. Clinical and genetic confirmation of FH index cases in the community may enhance the early detection of affected family members through family cascade...
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Dr Hamid3yrprevalence of genetically confirmed FH and the detection rate of pathogenic variants (PV) amongst clinically diagnosed patients is not well established
Empagliflozin benefits in patients with heart failure and preserved ejection fraction - Nature Medicine
Source : https://www.nature.com/articles/s41591-022-02050-4
Subgroup analysis of the EMPEROR-Preserved clinical trial of the glucose-lowering drug empagliflozin in chronic heart failure with left ventricular ejection fraction (LVEF) >40% found improved clinical outcomes in the cohort...
Conclusion: Subgroup analysis of the EMPEROR-Preserved clinical trial of the glucose-lowering drug empagliflozin in chronic heart failure with left ventricular ejection fraction (LVEF) >40% found improved clinical outcomes in the cohort of patients with LVEF ≥50%.
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Real-world safety of PCSK9 inhibitors: A pharmacovigilance study based on spontaneous reports in FAERS
Source : https://www.frontiersin.org/articles/10.3389/fphar.2022.894685/full
Objective: We aimed to evaluate alirocumab- and evolocumab-related adverse events (AEs) in real-world compared with all other drugs, overall and by gender and age subgroups; we also aimed to compare...
Conclusion: Real-world evidence showed that PCSK9 inhibitors were associated with an increased risk of musculoskeletal and connective tissue disorders and general disorders and administration site conditions, overall and by subgroups. Muscle toxicity, injection site reactions, and influenza-like illness were significant AE signals. Compared...
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The Impact of PCSK9 Modulation on Cardiovascular Outcomes: Recent Advances and the Managed Care Implications
To claim CE credit for this activity, please visit ABSTRACT http://www.pharmacytimes.org/pcsk9-ajmc Am J Manag Care. 2022;28(suppl 8):S139-S147. https://doi.org/10.37765/ajmc.2022.89269 Introduction to Hypercholesterolemia: Epidemiology and the Burden of Disease Cardiovascular disease (CVD)...
Conclusions/Relevance: Managed care professionals have considerable experience with developing approaches to providing access to novel injectable lipid-lowering therapies, such as alirocumab and evolocumab, and with the approval of inclisiran, they now have an expanding list of such therapies to incorporate into their care plans.
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Bempedoic acid, an ATP citrate lyase inhibitor, reduces intimal hyperplasia via activation of AMPKα signaling pathway
Source : https://www.sciencedirect.com/science/article/pii/S1567576922008761?via=ihub
* ACLY was firstly demonstrated to be significantly increased in PDGF-BB induced dedifferentiated smooth muscle cells. * * Bempedoic acid significantly reduced ACLY expression and inhibited VSMC dedifferentiation in the...
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Conclusions: We demonstrates that bempedoic acid reduces ACLY expression to restrain VSMC proliferation and dedifferentiation by activating AMPK/ACC signaling pathway, which may provide a potential therapeutic strategy for diseases associated with intimal hyperplasia including restenosis and atherosclerosis.
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