Current Options and Future Perspectives in the Treatment of Dyslipidemia - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36012957/
Low-density lipoprotein cholesterol (LDL-C) plays a crucial role in the development of atherosclerosis. Statin therapy is the standard treatment for lowering LDL-C in primary and secondary prevention. However, some patients...
Conclusion: This narrative review provides an overview of the new drugs for the treatment of dyslipidemia, their current status, ongoing clinical or preclinical trials, and their prospects. We also discuss the new alternative therapies for the treatment of dyslipidemia and their relevance to practice.
Share
Effect of Empagliflozin on Circulating Proteomics in Heart Failure: Mechanistic Insights from the EMPEROR Program - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/36017745/
Changes in circulating protein levels in patients with heart failure are consistent with the findings of experimental studies that have shown that the effects of SGLT2 inhibitors are likely related...
Conclusions: Changes in circulating protein levels in patients with heart failure are consistent with the findings of experimental studies that have shown that the effects of SGLT2 inhibitors are likely related to actions on the heart and kidney to promote autophagic flux, nutrient deprivation signaling and transmembrane sodium transport.
Share
Measures of Financial Hardship From Health Care Expenses Among Families With a Member With Atherosclerotic Cardiovascular Disease in the US
Source : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9308060/
JAMA Health Forum. 2022 Jul; 3(7): e221962. Stephen Y. Wang, MD, MPH, 1 Javier Valero-Elizondo, MD, MPH, 2 , 3 Miguel Cainzos-Achirica, MD, PhD, 2 , 3 Nihar R. Desai,...
Conclusions and Relevance: In this cross-sectional study of US adults, 2 in 5 families of patients with ASCVD experienced health care–related financial hardship, but a focus on objective or subjective measures alone would have captured only half the burden and not identified those deferring health care. The findings suggest that a...
Share
-
Dr Hamid3yrPatients with atherosclerotic cardiovascular disease (ASCVD) face substantial financial burden from health care costs as assessed by many disparate measures
Saturated Fatty Acid-Induced Impairment of Hepatic Lipid Metabolism Is Worsened by Prohibitin 1 Deficiency in Hepatocytes - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35980329/
Obesity-associated nonalcoholic fatty liver disease (NAFLD) is characterized by excessive intrahepatic lipid accumulation. Despite the increasing prevalence of NAFLD and obesity, the pathogenesis of NAFLD has not yet been clearly...
Relevance: In this study, we investigated how PHB1 affects lipid metabolism in murine hepatocytes. To reduce the expression of PHB1, Phb1 small interfering RNA was transfected into normal murine hepatocytes (AML12), and the cells were treated with the saturated fatty acid (SFA), palmitic acid (PA), for 24 h.
Share
-
Dr Hamid3yrDespite the increasing prevalence of NAFLD and obesity, the pathogenesis of NAFLD has not yet been clearly elucidated.
Ocular Disorders Associated with PCSK9 Inhibitors: A Pharmacovigilance Disproportionality Analysis - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/35973681/
doi: 10.1111/bcp.15494. Online ahead of print. 1 Department of Pharmacy, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. 2 School of Pharmacy, Chongqing Medical University, Chongqing, China. doi:...
Conclusion: This pharmacovigilance study identified a possible signal of ocular disorders associated with PCSK9 inhibitors and encourages paying attention to at-risk populations in PCSK9 inhibitors medication.
Share