International Journal of Medical Biochemistry
Source : https://internationalbiochemistry.com/jvi.aspx?pdir=ijmb&plng=eng&un=IJMB-28190&look4=
Int J Med Biochem . Ahead of Print: IJMB-28190 Hacer Eroğlu 1, Arif Murat Kaytaz 2, Evin Ademoglu 2, Sema Genc 3 1Istanbul Bakırköy Prof.Dr.Mazhar Osman Mental Health And Nerve...
Discussion and Conclusion: This study emphasizes the importance of determining lipid profiles during childhood and adolescence and taking preventive actions for cardiovascular diseases by implementing reliable age- and sex-specific cutoff values.
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Polygenic contribution for familial hypercholesterolemia (FH) - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34751168/
Polygenic risk scores have revealed to be important tools to define the cause of hypercholesterolemia in FH mutation-negative individuals and should be included in FH diagnosis strategies, although there is...
Summary: Polygenic risk scores have revealed to be important tools to define the cause of hypercholesterolemia in FH mutation-negative individuals and should be included in FH diagnosis strategies, although there is still space for more specific LDL-C GRS to be developed. The use of GRS may be used to refine cardiovascular risk prediction in FH...
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Conclusions: Total cholesterol, non-high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol were positively associated with the presence of carotid IPN in a Chinese high-stroke-risk population. Further prospective studies should be conducted to better understand how much finding IPN adds to current stroke prediction...
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Association between small dense low-density lipoprotein cholesterol and neuroimaging markers of cerebral small vessel disease in middle-aged and elderly Chinese populations - PubMed
Source : https://pubmed.ncbi.nlm.nih.gov/34753453/
The results indicate that LDL-C3 is an independent risk factor for CSVD. A new prediction model based on LDL-C3 and LDL-C4 can help clinicians identify high-risk CSVD, even in people...
Conclusion: The results indicate that LDL-C3 is an independent risk factor for CSVD. A new prediction model based on LDL-C3 and LDL-C4 can help clinicians identify high-risk CSVD, even in people with normal LDL-C levels. The levels of sdLDL-C should be considered in the assessment and management of CSVD.
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Leqvio®* (inclisiran) reduced LDL-C in people who are overweight or obese
Regardless of body mass index (BMI), Leqvio provided sustained and effective LDL-C reduction of ~50% with two doses a year**, according to pooled analysis of three Phase III studies Being...
“For patients with vascular disease who have a high BMI, physicians generally recommend weight loss in addition to cholesterol-lowering medication," said Lawrence A. Leiter, MD, Director of the Lipid Clinic, Associate Director of the Clinical Nutrition and Risk Factor Modification Centre and Associate Scientist in the Li Ka Shing Knowledge...
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