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4yr

Cholesterol – the devil you know; ceramide – the devil you don’t

Source : https://doi.org/10.1016/j.tips.2021.10.001



Highlights:

  • Pioneering studies on cholesterol have revolutionized our understanding of the role of lipids in cardiovascular disease.
  • The widely prescribed statins inhibit cholesterol biosynthesis to prevent coronary artery disease.
  • By lowering liver cholesterol, statins reduce levels of circulating lipoproteins and decrease levels of...

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    4yr

    Spectrum of Apolipoprotein AI and Apolipoprotein AII Proteoforms and Their Associations With Indices of Cardiometabolic Health: The CARDIA Study

    Source : https://www.ahajournals.org/doi/full/10.1161/JAHA.120.019890



    Conclusions: Associations between apoAI and AII and cardiometabolic indices are proteoform‐specific. These results provide “proof‐of‐concept” that precise chemical characterization of human apolipoproteins will yield improved insights into the complex pathways through which proteins signify and mediate health and disease.

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    4yr
    Triglyceride glucose index influences platelet reactivity in acute ischemic stroke patients - BMC Neurology

    Triglyceride glucose index influences platelet reactivity in acute ischemic stroke patients - BMC Neurology

    Source : https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-021-02443-x

    Aim Insulin resistance was reported to increase the risk of ischemic stroke, which can be assessed by the triglyceride glucose (TyG) index. However, it remains unclear whether the TyG index...



    Conclusions: In acute ischemic stroke patients taking DAPT, the elevation of the TyG index is associated with enhanced platelet reactivity and higher prevalence of aspirin HRPR. Insulin resistance assessed by the TyG index could be an independent risk factor for aspirin HRPR.

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      Key Points • Source: BMC Neurology • Conclusion/Relevance: “In acute ischemic stroke patients taking dual antiplatelet therapy [DAPT], the elevation of the triglyceride glucose [TyG] index is associated with enhanced platelet reactivity and higher Show More
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    4yr
    Low−/high-density lipoprotein cholesterol ratio and carotid plaques in patients with coronary heart disease: a Chinese cohort study - Lipids in Health and Disease

    Low−/high-density lipoprotein cholesterol ratio and carotid plaques in patients with coronary heart disease: a Chinese cohort study - Lipids in Health and Disease

    Source : https://lipidworld.biomedcentral.com/articles/10.1186/s12944-021-01575-w

    Background Evidence on the relationship between the low−/high-density lipoprotein cholesterol ratio (LDL-C/HDL-C) and carotid plaques remains limited. This study aimed to examine the association between LDL-C/HDL-C and carotid plaques in...



    Conclusion: A high LDL-C/HDL-C is associated with a risk of carotid plaques developing in CHD patients. Adhering to a healthy lifestyle has additive beneficial effects on reducing the risk of carotid plaques, especially in relation to the highest LDL-C/HDL-C.

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    • 4yr
      Interesting article & emphasizes need of healthy lifestyle & beneficial effects on reducing risk of carotid plaques !!!
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    4yr

    Association between LDL-C/HDL-C Ratio and Carotid Atherosclerosis in an Asymptomatic Japanese Population: A Cross-Sectional Study

    Source : https://europepmc.org/article/ppr/ppr411122

    Background: and aims LDL-C/HDL-C ratio predicted atherosclerosis progression better than LDL-C or HDL-C alone. However, the association between LDL-C/HDL-C ratio and Carotid Atherosclerosis(CA) is still controversial. There is a lack...



    Conclusions: In conclusion, LDL-C/HDL-C ratio is an independent risk factor for CA in the Japanese population. A prospective and randomized clinical trial of LDL-C/HDL-C ratio lowering therapy in the Japanese population is needed to assess the causal nature of the relationship.

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